Seroatlas · Human Serome Atlas

KBTBD11

Kelch repeat and BTB domain-containing protein 11

Also known as: KBTBB_HUMAN, KIAA0711, KLHDC7C

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O94819
Gene: KBTBD11
Ensembl: ENSG00000176595
Chromosome: 8
Canonical length: 623 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Intermediate filaments

OverviewNCBI Gene

No narrative summary is available for KBTBD11 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

623 residues, UniProt reviewed canonical sequence.

>O94819|KBTBD11
     1  MEHAVAPCVL YPGTEPGAAG ESESEGAASP AQTPCSLGAS LCFSSGEESP PQSLASAAEG
    61  AATSPPSSGG PRVVERQWEA GSAGAASPEE LASPEERACP EEPAAPSPEP RVWLEDPASP
   121  EEPGEPAPVP PGFGAVYGEP DLVLEVSGRR LRAHKAVLAA RSDYFRARAS RDVLRVQGVS
   181  LTALRLLLAD AYSGRMAGVR PDNVAEVVAG ARRLQLPGAA QRATDAVGPQ LSLANCYEVL
   241  SAAKRQRLNE LRDAAYCFMS DHYLEVLREP AVFGRLSGAE RDLLLRRRLR AGRAHLLAAA
   301  LGPAGERAGS RPQSPSGDAD ARGDAAVYCF HAAAGEWREL TRLPEGAPAR GCGLCVLYNY
   361  LFVAGGVAPA GPDGRARPSD QVFCYNPATD SWSAVRPLRQ ARSQLRLLAL DGHLYAVGGE
   421  CLLSVERYDP RADRWAPVAP LPRGAFAVAH EATTCHGEIY VSGGSLFYRL LKYDPRRDEW
   481  QECPCSSSRE RSADMVALDG FIYRFDLSGS RGEAQAAGPS GVSVSRYHCL AKQWSPCVAP
   541  LRLPGGPTGL QPFRCAALDG AIYCVSRAGT WRFQPAREGE AGGDAGQGGG FEALGAPLDV
   601  RGVLIPFALS LPEKPPRGEQ GAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KBTBD11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 35 nTPM
amygdala: 27 nTPM
basal ganglia: 27 nTPM
hippocampal formation: 25 nTPM
cerebellum: 24 nTPM
midbrain: 22 nTPM

Single-cell type

podocytes: 42 nCPM
astrocytes: 32 nCPM
proximal tubule cells: 31 nCPM
brain excitatory neurons: 26 nCPM
loop of henle epithelial cells: 23 nCPM
ependymal cells: 21 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 71 nTPM
white matter: 68 nTPM
hippocampal formation: 65 nTPM
medulla oblongata: 62 nTPM
basal ganglia: 58 nTPM
spinal cord: 55 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0.06
gnomAD missense Z: 0.51
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KBTBD11 as an antibody target. Whether an autoantibody or antibody against KBTBD11 could matter depends on whether native KBTBD11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KBTBD11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KBTBD11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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