Seroatlas · Human Serome Atlas

ABTB1

Ankyrin repeat and BTB/POZ domain-containing protein 1

Also known as: ABTB1_HUMAN, BPOZ, Btb3, BTBD21, EF1ABP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q969K4
Gene
ABTB1
Ensembl
ENSG00000114626
Chromosome
3
Canonical length
478 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli,Cytosol

OverviewNCBI Gene

This gene encodes a protein with an ankyrin repeat region and two BTB/POZ domains, which are thought to be involved in protein-protein interactions. Expression of this gene is activated by the phosphatase and tensin homolog, a tumor suppressor. Alternate splicing results in three transcript variants. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

478 residues, UniProt reviewed canonical sequence.

>Q969K4|ABTB1
     1  MDTSDLFASC RKGDVGRVRY LLEQRDVEVN VRDKWDSTPL YYACLCGHEE LVLYLLANGA
    61  RCEANTFDGE RCLYGALSDP IRRALRDYKQ VTASCRRRDY YDDFLQRLLE QGIHSDVVFV
   121  VHGKPFRVHR CVLGARSAYF ANMLDTKWKG KSVVVLRHPL INPVAFGALL QYLYTGRLDI
   181  GVEHVSDCER LAKQCQLWDL LSDLEAKCEK VSEFVASKPG TCVKVLTIEP PPADPRLRED
   241  MALLADCALP PELRGDLWEL PFPCPDGFNS CPDICFRVAG CSFLCHKAFF CGRSDYFRAL
   301  LDDHFRESEE PATSGGPPAV TLHGISPDVF THVLYYMYSD HTELSPEAAY DVLSVADMYL
   361  LPGLKRLCGR SLAQMLDEDT VVGVWRVAKL FRLARLEDQC TEYMAKVIEK LVEREDFVEA
   421  VKEEAAAVAA RQETDSIPLV DDIRFHVAST VQTYSAIEEA QQRLRALEDL LVSIGLDC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABTB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
101 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 101 nTPM
  • spleen: 95 nTPM
  • cerebral cortex: 51 nTPM
  • bone marrow: 48 nTPM
  • blood vessel: 47 nTPM
  • skeletal muscle: 44 nTPM

Single-cell type

  • neutrophils: 611 nCPM
  • platelets: 176 nCPM
  • neutrophil progenitors: 146 nCPM
  • kupffer cells: 66 nCPM
  • vascular smooth muscle cells: 54 nCPM
  • monocytes: 50 nCPM

Immune cell

  • neutrophil: 825 nTPM
  • eosinophil: 162 nTPM
  • classical monocyte: 65 nTPM
  • intermediate monocyte: 48 nTPM
  • T-reg: 47 nTPM
  • total PBMC: 46 nTPM

Brain region

  • cerebellum: 48 nTPM
  • basal ganglia: 44 nTPM
  • cerebral cortex: 42 nTPM
  • hippocampal formation: 37 nTPM
  • amygdala: 33 nTPM
  • white matter: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.76
gnomAD pLI
0
gnomAD missense Z
0.34
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ABTB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABTB1 as an antibody target. Whether an autoantibody or antibody against ABTB1 could matter depends on whether native ABTB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABTB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ABTB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ABTB1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...