Seroatlas · Human Serome Atlas

ZBTB2

Zinc finger and BTB domain-containing protein 2

Also known as: bA351K16.2, KIAA1483, ZBTB2_HUMAN, ZNF437

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N680
Gene: ZBTB2
Ensembl: ENSG00000181472
Chromosome: 6
Canonical length: 514 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

514 residues, UniProt reviewed canonical sequence.

>Q8N680|ZBTB2
     1  MDLANHGLIL LQQLNAQREF GFLCDCTVAI GDVYFKAHKS VLASFSNYFK MLFVHQTSEC
    61  VRLKPTDIQP DIFSYLLHLM YTGKMAPQLI DPVRLEQGIK FLHAYPLIQE ASLASQGAFS
   121  HPDQVFPLAS SLYGIQIADH QLRQATKIAS APEKLGRDPR PQTSRISQEQ VPEASQLSQL
   181  TSNLAQVNRT NMTPSDPLQT SLSPELVSTP VPPPPPGEET NLEASSSDEQ PASLTIAHVK
   241  PSIMKRNGSF PKYYACHLCG RRFTLRSSLR EHLQIHTGVP FTSSQQGESR VPLTLCSNAA
   301  DLGKDAMEVP EAGMISDSEL QHISDSPIID GQQQSETPPP SDIADIDNLE QADQEREVKR
   361  RKYECTICGR KFIQKSHWRE HMYIHTGKPF KCSTCDKSFC RANQAARHVC LNQSIDTYTM
   421  VDKQTLELCT FEEGSQMDNM LVQTNKPYKC NLCDKTFSTP NEVVKHSCQN QNSDVFALDE
   481  GRSILLGSGD SEVTEPDHPV LASIKKEQET VLLD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBTB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 28 nTPM
thymus: 19 nTPM
bone marrow: 15 nTPM
lymph node: 13 nTPM
tonsil: 12 nTPM
ovary: 11 nTPM

Single-cell type

endometrial luminal cells: 87 nCPM
endometrial glandular cells: 61 nCPM
cardiomyocytes: 53 nCPM
epicardial cells: 52 nCPM
endometrial stromal cells: 42 nCPM
extravillous trophoblasts: 40 nCPM

Immune cell

basophil: 19 nTPM
eosinophil: 17 nTPM
MAIT T-cell: 14 nTPM
memory CD8 T-cell: 14 nTPM
non-classical monocyte: 13 nTPM
gdT-cell: 11 nTPM

Brain region

white matter: 10 nTPM
cerebellum: 9.4 nTPM
pons: 8.5 nTPM
medulla oblongata: 8.4 nTPM
cerebral cortex: 8.3 nTPM
midbrain: 8.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.16
gnomAD pLI: 1
gnomAD missense Z: 2.64
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZBTB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZBTB2 as an antibody target. Whether an autoantibody or antibody against ZBTB2 could matter depends on whether native ZBTB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZBTB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZBTB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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