Seroatlas · Human Serome Atlas

BTBD7

BTB/POZ domain-containing protein 7

Also known as: BTBD7_HUMAN, FLJ10648, FUP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P203
Gene: BTBD7
Ensembl: ENSG00000011114
Chromosome: 14
Canonical length: 1132 aa
Protein class: Predicted intracellular proteins
Subcellular location: Focal adhesion sites

OverviewNCBI Gene

Predicted to be involved in regulation of branching involved in salivary gland morphogenesis. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1132 residues, UniProt reviewed canonical sequence.

>Q9P203|BTBD7
     1  MGANASNYPH SCSPRVGGNS QAQQTFIGTS SYSQQGYGCE SKLYSLDHGH EKPQDKKKRT
    61  SGLATLKKKF IKRRKSNRSA DHAKQMRELL SGWDVRDVNA LVEEYEGTSA LKELSLQASL
   121  ARPEARTLQK DMADLYEYKY CTDVDLIFQE TCFPVHRAIL AARCPFFKTL LSSSPEYGAE
   181  IIMDINTAGI DMPMFSALLH YLYTGEFGME DSRFQNVDIL VQLSEEFGTP NSLDVDMRGL
   241  FDYMCYYDVV LSFSSDSELV EAFGGNQNCL DEELKAHKAV ISARSPFFRN LLQRRIRTGE
   301  EITDRTLRTP TRIILDESII PKKYATVILH CMYTDVVDLS VLHCSPSVGS LSEVQALVAG
   361  KPNMTRAEEA MELYHIALFL EFNMLAQGCE DIIAESISLD TLIAILKWSS HPYGSKWVHR
   421  QALHFLCEEF SQVMTSDVFY ELSKDHLLTA IQSDYLQASE QDILKYLIKW GEHQLMKRIA
   481  DREPNLLSGT AHSVNKRGVK RRDLDMEELR EILSSLLPFV RIEHILPINS EVLSDAMKRG
   541  LISTPPSDML PTTEGGKSNA WLRQKNAGIY VRPRLFSPYV EEAKSVLDEM MVEQTDLVRL
   601  RMVRMSNVPD TLYMVNNAVP QCCHMISHQQ ISSNQSSPPS VVANEIPVPR LLIMKDMVRR
   661  LQELRHTEQV QRAYALNCGE GATVSYEIQI RVLREFGLAD AAAELLQNPH KFFPDERFGD
   721  ESPLLTMRQP GRCRVNSTPP AETMFTDLDS FVAFHPPLPP PPPPYHPPAT PIHNQLKAGW
   781  KQRPPSQHPS RSFSYPCNHS LFHSRTAPKA GPPPVYLPSV KAAPPDCTST AGLGRQTVAA
   841  AAATTTSTAT AAAAAASEKQ VRTQPVLNDL MPDIAVGVST LSLKDRRLPE LAVDTELSQS
   901  VSEAGPGPPQ HLSCIPQRHT HTSRKKHTLE QKTDTRENPQ EYPDFYDFSN AACRPSTPAL
   961  SRRTPSPSQG GYFGPDLYSH NKASPSGLKS AYLPGQTSPK KQEEARREYP LSPDGHLHRQ
  1021  KNEPIHLDVV EQPPQRSDFP LAAPENASTG PAHVRGRTAV ETDLTFGLTP NRPSLSACSS
  1081  EAPEERSGRR LADSESLGHG AQRNTDLERE DSISRGRRSP SKPDFLYKKS AL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BTBD7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 7.4 nTPM

Expression across tissuesHPA

Tissue

testis: 7.4 nTPM
bone marrow: 5.3 nTPM
blood vessel: 4.3 nTPM
esophagus: 4.2 nTPM
skeletal muscle: 4.2 nTPM
parathyroid gland: 3.8 nTPM

Single-cell type

bergmann glia: 279 nCPM
renal connecting tubule cells: 269 nCPM
microglia: 232 nCPM
proximal tubule cells: 212 nCPM
oligodendrocytes: 205 nCPM
distal convoluted tubule cells: 195 nCPM

Immune cell

eosinophil: 1.4 nTPM
basophil: 0.8 nTPM
memory B-cell: 0.6 nTPM
neutrophil: 0.6 nTPM
T-reg: 0.5 nTPM
naive B-cell: 0.4 nTPM

Brain region

white matter: 19 nTPM
thalamus: 19 nTPM
cerebellum: 19 nTPM
midbrain: 18 nTPM
medulla oblongata: 17 nTPM
pons: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.51
gnomAD pLI: 0
gnomAD missense Z: 0.92
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

BTB/POZ domain
SKP1/BTB/POZ domain superfamily
BTB/Kelch-associated
BTB/POZ domain
BTB And C-terminal Kelch
BTB/POZ domain-containing protein 7
BTBD7, first BTB/POZ domain
BTBD7, second BTB/POZ domain
BTBD7, BACK domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BTBD7 as an antibody target. Whether an autoantibody or antibody against BTBD7 could matter depends on whether native BTBD7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BTBD7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BTBD7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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