Seroatlas · Human Serome Atlas

ZBTB9

Zinc finger and BTB domain-containing protein 9

Also known as: MGC23166, ZBTB9_HUMAN, ZNF919

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96C00
Gene
ZBTB9
Ensembl
ENSG00000213588
Chromosome
6
Canonical length
473 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear membrane,Cytosol

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

473 residues, UniProt reviewed canonical sequence.

>Q96C00|ZBTB9
     1  METPTPLPPV PASPTCNPAP RTIQIEFPQH SSSLLESLNR HRLEGKFCDV SLLVQGRELR
    61  AHKAVLAAAS PYFHDKLLLG DAPRLTLPSV IEADAFEGLL QLIYSGRLRL PLDALPAHLL
   121  VASGLQMWQV VDQCSEILRE LETSGGGISA RGGNSYHALL STTSSTGGWC IRSSPFQTPV
   181  QSSASTESPA STESPVGGEG SELGEVLQIQ VEEEEEEEED DDDEDQGSAT LSQTPQPQRV
   241  SGVFPRPHGP HPLPMTATPR KLPEGESAPL ELPAPPALPP KIFYIKQEPF EPKEEISGSG
   301  TQPGGAKEET KVFSGGDTEG NGELGFLLPS GPGPTSGGGG PSWKPVDLHG NEILSGGGGP
   361  GGAGQAVHGP VKLGGTPPAD GKRFGCLCGK RFAVKPKRDR HIMLTFSLRP FGCGICNKRF
   421  KLKHHLTEHM KTHAGALHAC PHCGRRFRVH ACFLRHRDLC KGQGWATAHW TYK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBTB9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • pituitary gland: 15 nTPM
  • testis: 8.9 nTPM
  • hippocampal formation: 4.7 nTPM
  • adrenal gland: 4.5 nTPM
  • cerebral cortex: 4.5 nTPM
  • basal ganglia: 4.4 nTPM

Single-cell type

  • choroid plexus epithelial cells: 11 nCPM
  • ependymal cells: 6 nCPM
  • brain excitatory neurons: 2.7 nCPM
  • astrocytes: 2.5 nCPM
  • other brain neurons: 1.9 nCPM
  • bergmann glia: 1.5 nCPM

Immune cell

  • basophil: 5.2 nTPM
  • gdT-cell: 2.8 nTPM
  • memory CD8 T-cell: 2.6 nTPM
  • naive CD4 T-cell: 2.5 nTPM
  • T-reg: 2.2 nTPM
  • naive CD8 T-cell: 1.9 nTPM

Brain region

  • choroid plexus: 20 nTPM
  • hippocampal formation: 5.5 nTPM
  • cerebral cortex: 4.9 nTPM
  • medulla oblongata: 4.2 nTPM
  • basal ganglia: 3.7 nTPM
  • amygdala: 3.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.74
gnomAD pLI
0.07
gnomAD missense Z
1.17
DepMap mean gene effect
-0.24
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZBTB9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZBTB9 as an antibody target. Whether an autoantibody or antibody against ZBTB9 could matter depends on whether native ZBTB9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZBTB9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZBTB9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZBTB9. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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