Seroatlas · Human Serome Atlas

ENC1

Ectoderm-neural cortex protein 1

Also known as: ENC-1, ENC1_HUMAN, KLHL37, NRPB, PIG10, TP53I10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14682
Gene
ENC1
Ensembl
ENSG00000171617
Chromosome
5
Canonical length
589 aa
Protein class
Cancer-related genes, Predicted intracellular proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

This gene encodes a member of the kelch-related family of actin-binding proteins. The encoded protein plays a role in the oxidative stress response as a regulator of the transcription factor Nrf2, and expression of this gene may play a role in malignant transformation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

589 residues, UniProt reviewed canonical sequence.

>O14682|ENC1
     1  MSVSVHENRK SRASSGSINI YLFHKSSYAD SVLTHLNLLR QQRLFTDVLL HAGNRTFPCH
    61  RAVLAACSRY FEAMFSGGLK ESQDSEVNFD NSIHPEVLEL LLDYAYSSRV IINEENAESL
   121  LEAGDMLEFQ DIRDACAEFL EKNLHPTNCL GMLLLSDAHQ CTKLYELSWR MCLSNFQTIR
   181  KNEDFLQLPQ DMVVQLLSSE ELETEDERLV YESAINWISY DLKKRYCYLP ELLQTVRLAL
   241  LPAIYLMENV AMEELITKQR KSKEIVEEAI RCKLKILQND GVVTSLCARP RKTGHALFLL
   301  GGQTFMCDKL YLVDQKAKEI IPKADIPSPR KEFSACAIGC KVYITGGRGS ENGVSKDVWV
   361  YDTLHEEWSK AAPMLVARFG HGSAELKHCL YVVGGHTAAT GCLPASPSVS LKQVEHYDPT
   421  INKWTMVAPL REGVSNAAVV SAKLKLFAFG GTSVSHDKLP KVQCYDQCEN RWTVPATCPQ
   481  PWRYTAAAVL GNQIFIMGGD TEFSACSAYK FNSETYQWTK VGDVTAKRMS CHAVASGNKL
   541  YVVGGYFGIQ RCKTLDCYDP TLDVWNSITT VPYSLIPTAF VSTWKHLPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ENC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
279 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 279 nTPM
  • hippocampal formation: 124 nTPM
  • amygdala: 106 nTPM
  • ovary: 43 nTPM
  • basal ganglia: 34 nTPM
  • pancreas: 31 nTPM

Single-cell type

  • brain excitatory neurons: 197 nCPM
  • pancreatic duct cells: 147 nCPM
  • mucous neck cells: 141 nCPM
  • granulosa cells: 131 nCPM
  • gastric progenitor cells: 106 nCPM
  • ocular epithelial cells: 100 nCPM

Immune cell

  • classical monocyte: 2.7 nTPM
  • eosinophil: 2.6 nTPM
  • intermediate monocyte: 2.3 nTPM
  • memory CD8 T-cell: 1.4 nTPM
  • NK-cell: 1.4 nTPM
  • naive CD8 T-cell: 1.3 nTPM

Brain region

  • hippocampal formation: 602 nTPM
  • cerebral cortex: 578 nTPM
  • basal ganglia: 391 nTPM
  • white matter: 334 nTPM
  • amygdala: 303 nTPM
  • pons: 131 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.49
gnomAD pLI
0.46
gnomAD missense Z
3.05
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ENC1 as an antibody target. Whether an autoantibody or antibody against ENC1 could matter depends on whether native ENC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ENC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ENC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ENC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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