Seroatlas · Human Serome Atlas

KCNV1

Potassium voltage-gated channel subfamily V member 1

Also known as: KCNV1_HUMAN, Kv8.1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6PIU1
Gene
KCNV1
Ensembl
ENSG00000164794
Chromosome
8
Canonical length
500 aa
Protein class
Predicted membrane proteins, Voltage-gated ion channels
Subcellular location
Plasma membrane,Cytokinetic bridge

OverviewNCBI Gene

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This protein is essentially present in the brain, and its role might be to inhibit the function of a particular class of outward rectifier potassium channel types. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

500 residues, UniProt reviewed canonical sequence.

>Q6PIU1|KCNV1
     1  MPSSGRALLD SPLDSGSLTS LDSSVFCSEG EGEPLALGDC FTVNVGGSRF VLSQQALSCF
    61  PHTRLGKLAV VVASYRRPGA LAAVPSPLEL CDDANPVDNE YFFDRSSQAF RYVLHYYRTG
   121  RLHVMEQLCA LSFLQEIQYW GIDELSIDSC CRDRYFRRKE LSETLDFKKD TEDQESQHES
   181  EQDFSQGPCP TVRQKLWNIL EKPGSSTAAR IFGVISIIFV VVSIINMALM SAELSWLDLQ
   241  LLEILEYVCI SWFTGEFVLR FLCVRDRCRF LRKVPNIIDL LAILPFYITL LVESLSGSQT
   301  TQELENVGRI VQVLRLLRAL RMLKLGRHST GLRSLGMTIT QCYEEVGLLL LFLSVGISIF
   361  STVEYFAEQS IPDTTFTSVP CAWWWATTSM TTVGYGDIRP DTTTGKIVAF MCILSGILVL
   421  ALPIAIINDR FSACYFTLKL KEAAVRQREA LKKLTKNIAT DSYISVNLRD VYARSIMEML
   481  RLKGRERAST RSSGGDDFWF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNV1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 13 nTPM
  • amygdala: 3.2 nTPM
  • hippocampal formation: 2.1 nTPM
  • basal ganglia: 1.9 nTPM
  • hypothalamus: 0.7 nTPM
  • colon: 0.4 nTPM

Single-cell type

  • brain excitatory neurons: 13 nCPM
  • paneth cells: 7.7 nCPM
  • neuroendocrine cells: 5.6 nCPM
  • enteric stem cells: 3.7 nCPM
  • brain inhibitory neurons: 3.3 nCPM
  • goblet cells: 2.2 nCPM

Immune cell

  • basophil: 0.5 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 24 nTPM
  • amygdala: 17 nTPM
  • basal ganglia: 16 nTPM
  • white matter: 15 nTPM
  • hippocampal formation: 15 nTPM
  • hypothalamus: 9.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.3
gnomAD pLI
0.98
gnomAD missense Z
4.07
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KCNV1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNV1 as an antibody target. Whether an autoantibody or antibody against KCNV1 could matter depends on whether native KCNV1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNV1 is annotated at the cell surface, where native KCNV1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCNV1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KCNV1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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