BTB/POZ domain
PF00651
Definition
The BTB (for BR-C, ttk and bab) PMID:7938017 or POZ (for Pox virus and Zinc finger) PMID:7958847 domain is present near the N-terminus of a fraction of zinc finger ([pfam:PF00096]) proteins and in proteins that contain the [pfam:PF01344] motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation PMID:7958847. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule PMID:9770450. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [[cite:PMID:9019154],[cite:PMID:9824158],[cite:PMID:9765306]]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
129 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Download CSV (129 proteins: gene, accession, name)
- ABTB1
- ABTB2
- ABTB3
- ANKFY1
- BACH1
- BACH2
- BCL6
- BCL6B
- BTBD1
- BTBD17
- BTBD18
- BTBD19
- BTBD2
- BTBD3
- BTBD6
- BTBD7
- BTBD8
- BTBD9
- CCIN
- ENC1
- GAN
- GMCL1
- GMCL2
- GZF1
- HIC1
- HIC2
- IBTK
- IPP
- IVNS1ABP
- KBTBD11
- KBTBD12
- KBTBD13
- KBTBD2
- KBTBD3
- KBTBD4
- KBTBD6
- KBTBD7
- KBTBD8
- KEAP1
- KLHL1
- KLHL10
- KLHL11
- KLHL12
- KLHL13
- KLHL14
- KLHL15
- KLHL17
- KLHL18
- KLHL2
- KLHL20
- KLHL21
- KLHL22
- KLHL23
- KLHL24
- KLHL25
- KLHL26
- KLHL28
- KLHL29
- KLHL3
- KLHL30
- KLHL31
- KLHL32
- KLHL34
- KLHL35
- KLHL36
- KLHL38
- KLHL4
- KLHL40
- KLHL41
- KLHL5
- KLHL6
- KLHL7
- KLHL8
- KLHL9
- LZTR1
- MYNN
- NACC1
- NACC2
- PATZ1
- RCBTB1
- RCBTB2
- RHOBTB1
- RHOBTB2
- RHOBTB3
- SLX4
- SPOP
- SPOPL
- ZBTB1
- ZBTB10
- ZBTB11
- ZBTB12
- ZBTB14
- ZBTB16
- ZBTB17
- ZBTB18
- ZBTB2
- ZBTB20
- ZBTB21
- ZBTB22
- ZBTB24
- ZBTB25
- ZBTB26
- ZBTB3
- ZBTB32
- ZBTB33
- ZBTB34
- ZBTB37
- ZBTB38
- ZBTB39
- ZBTB4
- ZBTB40
- ZBTB41
- ZBTB42
- ZBTB43
- ZBTB44
- ZBTB45
- ZBTB46
- ZBTB47
- ZBTB48
- ZBTB49
- ZBTB5
- ZBTB6
- ZBTB7A
- ZBTB7B
- ZBTB7C
- ZBTB8A
- ZBTB8B
- ZBTB9
- ZNF131
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