Seroatlas · Protein domains

NAD(P)-binding domain superfamily

IPR036291

Definition

This entry represents NAD- and NADP-binding domains superfamily with a core Rossmann-type fold, which consists of three layers (α/β/α) with parallel β-sheet of 6 strands. Many different enzymes contain an NAD/NADP-binding domain, including: C-terminal domain of alcohol dehydrogenases PMID:15449945 Tyrosine-dependent oxidoreductases (also known as short-chain dehydrogenases) PMID:9174344 N-terminal domain of glyceraldehyde-3-phosphate dehydrogenase PMID:10448043 NAD-binding domain of formate/glycerate dehydrogenases PMID:8114093 N-terminal domain of sirohaem synthase PMID:14595395 N-terminal domain of lactate dehydrogenase PMID:11276087 N-terminal domain of 6-phosphogluconate dehydrogenase (the β-sheet is extended to 8 strands) PMID:17222187 C-terminal domain of amino acid dehydrogenases (an extra N-terminal helix displaces the C-terminal helix PMID:8591026 NAD-binding domain of certain potassium channels PMID:11301020 C-terminal domain of the transcriptional repressor Rex PMID:15642260 Ornithine cyclodeaminase PMID:15518536 CoA-binding N-terminal domain of the alpha chain of succinyl-CoA synthetase PMID:9917402

155 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (155 proteins: gene, accession, name)

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