PTGR1

Protein identityUniProt · HPA

UniProt accession

Q14914

Gene

PTGR1

Ensembl

ENSG00000106853

Chromosome

9

Canonical length

329 aa

Protein class

Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

Canonical amino-acid sequenceUniProt

329 residues, UniProt reviewed canonical sequence.

>Q14914|PTGR1
     1  MVRTKTWTLK KHFVGYPTNS DFELKTAELP PLKNGEVLLE ALFLTVDPYM RVAAKRLKEG
    61  DTMMGQQVAK VVESKNVALP KGTIVLASPG WTTHSISDGK DLEKLLTEWP DTIPLSLALG
   121  TVGMPGLTAY FGLLEICGVK GGETVMVNAA AGAVGSVVGQ IAKLKGCKVV GAVGSDEKVA
   181  YLQKLGFDVV FNYKTVESLE ETLKKASPDG YDCYFDNVGG EFSNTVIGQM KKFGRIAICG
   241  AISTYNRTGP LPPGPPPEIV IYQELRMEAF VVYRWQGDAR QKALKDLLKW VLEGKIQYKE
   301  YIIEGFENMP AAFMGMLKGD NLGKTIVKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTGR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.24

Highest tissue expression

556 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.3

gnomAD pLI

0

gnomAD missense Z

0.41

DepMap mean gene effect

-0.05

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• leukotriene metabolic process
• lipoxin A4 metabolic process
• prostaglandin metabolic process
• leukotriene B4 metabolic process

Molecular functions

• 15-oxoprostaglandin 13-reductase [NAD(P)+] activity
• 13-lipoxin reductase activity
• 2-alkenal reductase (NADPH) activity
• leukotriene B4 12-hydroxy dehydrogenase activity

Cellular components

• cytoplasm
• extracellular exosome

Protein domainsUniProt · Pfam · InterPro

• GroES-like superfamily
• Alcohol dehydrogenase-like, C-terminal
• Enoylreductase domain
• NAD(P)-binding domain superfamily
• Oxidoreductase, N-terminal domain
• Medium-chain dehydrogenase/reductase
• Zinc-binding dehydrogenase
• N-terminal domain of oxidoreductase
• Leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase

KeywordsUniProt

• Acetylation
• Cytoplasm
• Fatty acid metabolism
• Hydroxylation
• Lipid metabolism
• NADP
• Oxidoreductase
• Phosphoprotein
• Prostaglandin metabolism