Seroatlas · Human Serome Atlas

CRYZ

Quinone oxidoreductase

Also known as: QOR_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q08257
Gene
CRYZ
Ensembl
ENSG00000116791
Chromosome
1
Canonical length
329 aa
Protein class
Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location
Cytosol
Quaternary structure
Homotetramer

OverviewNCBI Gene

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One pseudogene is known to exist. [provided by RefSeq, Sep 2008]

Canonical amino-acid sequenceUniProt

329 residues, UniProt reviewed canonical sequence.

>Q08257|CRYZ
     1  MATGQKLMRA VRVFEFGGPE VLKLRSDIAV PIPKDHQVLI KVHACGVNPV ETYIRSGTYS
    61  RKPLLPYTPG SDVAGVIEAV GDNASAFKKG DRVFTSSTIS GGYAEYALAA DHTVYKLPEK
   121  LDFKQGAAIG IPYFTAYRAL IHSACVKAGE SVLVHGASGG VGLAACQIAR AYGLKILGTA
   181  GTEEGQKIVL QNGAHEVFNH REVNYIDKIK KYVGEKGIDI IIEMLANVNL SKDLSLLSHG
   241  GRVIVVGSRG TIEINPRDTM AKESSIIGVT LFSSTKEEFQ QYAAALQAGM EIGWLKPVIG
   301  SQYPLEKVAE AHENIIHGSG ATGKMILLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRYZ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
309 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 309 nTPM
  • liver: 264 nTPM
  • epididymis: 114 nTPM
  • choroid plexus: 88 nTPM
  • gallbladder: 65 nTPM
  • pancreas: 59 nTPM

Single-cell type

  • oocytes: 263 nCPM
  • hepatocytes: 261 nCPM
  • epididymal efferent duct ciliated cells: 131 nCPM
  • epididymal efferent duct absorptive cells: 118 nCPM
  • epididymal principal cells: 106 nCPM
  • fallopian tube ciliated cells: 103 nCPM

Immune cell

  • T-reg: 43 nTPM
  • memory B-cell: 33 nTPM
  • gdT-cell: 32 nTPM
  • memory CD4 T-cell: 32 nTPM
  • NK-cell: 30 nTPM
  • memory CD8 T-cell: 30 nTPM

Brain region

  • choroid plexus: 94 nTPM
  • midbrain: 33 nTPM
  • white matter: 32 nTPM
  • pons: 32 nTPM
  • thalamus: 31 nTPM
  • hypothalamus: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.93
gnomAD pLI
0
gnomAD missense Z
0.38
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CRYZ as an antibody target. Whether an autoantibody or antibody against CRYZ could matter depends on whether native CRYZ is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CRYZ is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CRYZ as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CRYZ. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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