STEAP3

Protein identityUniProt · HPA

UniProt accession

Q658P3

Gene

STEAP3

Ensembl

ENSG00000115107

Chromosome

2

Canonical length

488 aa

Protein class

Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters

Subcellular location

Nucleoli,Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a multipass membrane protein that functions as an iron transporter. The encoded protein can reduce both iron (Fe3+) and copper (Cu2+) cations. This protein may mediate downstream responses to p53, including promoting apoptosis. Deficiency in this gene can cause anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Canonical amino-acid sequenceUniProt

488 residues, UniProt reviewed canonical sequence.

>Q658P3|STEAP3
     1  MPEEMDKPLI SLHLVDSDSS LAKVPDEAPK VGILGSGDFA RSLATRLVGS GFKVVVGSRN
    61  PKRTARLFPS AAQVTFQEEA VSSPEVIFVA VFREHYSSLC SLSDQLAGKI LVDVSNPTEQ
   121  EHLQHRESNA EYLASLFPTC TVVKAFNVIS AWTLQAGPRD GNRQVPICGD QPEAKRAVSE
   181  MALAMGFMPV DMGSLASAWE VEAMPLRLLP AWKVPTLLAL GLFVCFYAYN FVRDVLQPYV
   241  QESQNKFFKL PVSVVNTTLP CVAYVLLSLV YLPGVLAAAL QLRRGTKYQR FPDWLDHWLQ
   301  HRKQIGLLSF FCAALHALYS FCLPLRRAHR YDLVNLAVKQ VLANKSHLWV EEEVWRMEIY
   361  LSLGVLALGT LSLLAVTSLP SIANSLNWRE FSFVQSSLGF VALVLSTLHT LTYGWTRAFE
   421  ESRYKFYLPP TFTLTLLVPC VVILAKALFL LPCISRRLAR IRRGWEREST IKFTLPTDHA
   481  LAEKTSHV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STEAP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

6

Mean surface accessibility (rSASA)

0.33

Highest tissue expression

180 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about STEAP3.

Disease | AllUniProt

Conditions STEAP3 is implicated in, by any mechanism.

• Anemia, hypochromic microcytic, with iron overload 2 (AHMIO2) MIM:615234

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.34

gnomAD pLI

0

gnomAD missense Z

-0.22

DepMap mean gene effect

-0.15

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• copper ion import
• iron ion transport
• protein secretion

Molecular functions

• cupric reductase (NADH) activity
• FAD binding
• ferric-chelate reductase (NADPH) activity
• heme binding
• identical protein binding
• metal ion binding

Cellular components

• cytoplasm
• endosome
• endosome membrane
• multivesicular body
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Ferric reductase transmembrane component-like domain
• Pyrroline-5-carboxylate reductase, catalytic, N-terminal
• NAD(P)-binding domain superfamily
• STEAP family metalloreductases
• Ferric reductase like transmembrane component
• NADP oxidoreductase coenzyme F420-dependent

KeywordsUniProt

• Apoptosis
• Cell cycle
• Copper
• Endosome
• FAD
• Flavoprotein
• Glycoprotein
• Heme
• Ion transport
• Iron
• Iron transport
• Membrane
• Metal-binding
• NADP
• Oxidoreductase
• Phosphoprotein
• Transmembrane
• Transmembrane helix
• Transport

InteractionsUniProt · HPA

Protein binding partners of STEAP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• BNIP3L
• MYT1
• TCTP
• TFRC
• RHBDD1
• TPT1