Seroatlas · Human Serome Atlas

RDH14

Retinol dehydrogenase 14

Also known as: PAN2, RDH14_HUMAN, SDR7C4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HBH5
Gene: RDH14
Ensembl: ENSG00000240857
Chromosome: 2
Canonical length: 336 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables all-trans-retinol dehydrogenase (NADP+) activity. Involved in osteoblast differentiation. Located in cytosol; endoplasmic reticulum; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

336 residues, UniProt reviewed canonical sequence.

>Q9HBH5|RDH14
     1  MAVATAAAVL AALGGALWLA ARRFVGPRVQ RLRRGGDPGL MHGKTVLITG ANSGLGRATA
    61  AELLRLGARV IMGCRDRARA EEAAGQLRRE LRQAAECGPE PGVSGVGELI VRELDLASLR
   121  SVRAFCQEML QEEPRLDVLI NNAGIFQCPY MKTEDGFEMQ FGVNHLGHFL LTNLLLGLLK
   181  SSAPSRIVVV SSKLYKYGDI NFDDLNSEQS YNKSFCYSRS KLANILFTRE LARRLEGTNV
   241  TVNVLHPGIV RTNLGRHIHI PLLVKPLFNL VSWAFFKTPV EGAQTSIYLA SSPEVEGVSG
   301  RYFGDCKEEE LLPKAMDESV ARKLWDISEV MVGLLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RDH14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 29 nTPM
skeletal muscle: 26 nTPM
tongue: 25 nTPM
liver: 18 nTPM
parathyroid gland: 18 nTPM
blood vessel: 17 nTPM

Single-cell type

late primary spermatocytes: 72 nCPM
extravillous trophoblasts: 62 nCPM
fallopian tube ciliated cells: 62 nCPM
early primary spermatocytes: 57 nCPM
migrating cytotrophoblasts: 55 nCPM
respiratory ciliated cells: 54 nCPM

Immune cell

naive B-cell: 12 nTPM
memory B-cell: 7.4 nTPM
eosinophil: 6.5 nTPM
plasmacytoid DC: 6.1 nTPM
naive CD4 T-cell: 5.6 nTPM
MAIT T-cell: 5.5 nTPM

Brain region

choroid plexus: 23 nTPM
white matter: 14 nTPM
pons: 13 nTPM
spinal cord: 13 nTPM
cerebellum: 13 nTPM
cerebral cortex: 12 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RDH14.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 73 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.8
gnomAD pLI: 0
gnomAD missense Z: -0.82
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

osteoblast differentiation

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RDH14 as an antibody target. Whether an autoantibody or antibody against RDH14 could matter depends on whether native RDH14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RDH14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RDH14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...