DHDH

Protein identityUniProt · HPA

UniProt accession

Q9UQ10

Gene

DHDH

Ensembl

ENSG00000104808

Chromosome

19

Canonical length

334 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Actin filaments

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

334 residues, UniProt reviewed canonical sequence.

>Q9UQ10|DHDH
     1  MALRWGIVSV GLISSDFTAV LQTLPRSEHQ VVAVAARDLS RAKEFAQKHD IPKAYGSYEE
    61  LAKDPSVEVA YIGTQHPQHK AAVMLCLAAG KAVLCEKPTG VNAAEVREMV AEARSRALFL
   121  MEAIWTRFFP ASEALRSVLA QGTLGDLRVA RAEFGKNLIH VPRAVDRAQA GGALLDIGIY
   181  CVQFTSMVFG GQKPEKISVV GRRHETGVDD TVTVLLQYPG EVHGSFTCSI TVQLSNTASV
   241  SGTKGMVQLL NPCWCPTELV VKGEHKEFPL PPVPKDCNFD NGAGMSYEAK HVWECLRKGM
   301  KESPVIPLSE SELLADILEE VRKAIGVTFP QDKR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DHDH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Unknown

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.21

Highest tissue expression

17 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.54

gnomAD pLI

0

gnomAD missense Z

0.1

DepMap mean gene effect

0.06

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• D-xylose catabolic process

Molecular functions

• nucleotide binding
• trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
• D-xylose 1-dehydrogenase (NADP+) activity

Protein domainsUniProt · Pfam · InterPro

• Gfo/Idh/MocA-like oxidoreductase, N-terminal
• NAD(P)-binding domain superfamily
• GFO/IDH/MocA-like oxidoreductase domain
• Oxidoreductase family, NAD-binding Rossmann fold
• GFO/IDH/MocA C-terminal domain
• Gfo/Idh/MocA domain-containing protein

KeywordsUniProt

• NADP
• Oxidoreductase