Seroatlas · Human Serome Atlas

VAT1L

Synaptic vesicle membrane protein VAT-1 homolog-like

Also known as: KIAA1576, VAT1L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HCJ6
Gene: VAT1L
Ensembl: ENSG00000171724
Chromosome: 16
Canonical length: 419 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable oxidoreductase activity and zinc ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

419 residues, UniProt reviewed canonical sequence.

>Q9HCJ6|VAT1L
     1  MAKEGVEKAE ETEQMIEKEA GKEPAEGGGG DGSHRLGDAQ EMRAVVLAGF GGLNKLRLFR
    61  KAMPEPQDGE LKIRVKACGL NFIDLMVRQG NIDNPPKTPL VPGFECSGIV EALGDSVKGY
   121  EIGDRVMAFV NYNAWAEVVC TPVEFVYKIP DDMSFSEAAA FPMNFVTAYV MLFEVANLRE
   181  GMSVLVHSAG GGVGQAVAQL CSTVPNVTVF GTASTFKHEA IKDSVTHLFD RNADYVQEVK
   241  RISAEGVDIV LDCLCGDNTG KGLSLLKPLG TYILYGSSNM VTGETKSFFS FAKSWWQVEK
   301  VNPIKLYEEN KVIAGFSLLN LLFKQGRAGL IRGVVEKLIG LYNQKKIKPV VDSLWALEEV
   361  KEAMQRIHDR GNIGKLILDV EKTPTPLMAN DSTETSEAGE EEEDHEGDSE NKERMPFIQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VAT1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 312 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 312 nTPM
retina: 175 nTPM
hypothalamus: 123 nTPM
basal ganglia: 79 nTPM
cerebellum: 74 nTPM
adrenal gland: 66 nTPM

Single-cell type

retinal horizontal cells: 1,663 nCPM
choroid plexus epithelial cells: 1,577 nCPM
bergmann glia: 677 nCPM
retinal pigment epithelial cells: 482 nCPM
adrenal medulla cells: 362 nCPM
other brain neurons: 208 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 502 nTPM
hypothalamus: 407 nTPM
pons: 185 nTPM
medulla oblongata: 132 nTPM
midbrain: 117 nTPM
spinal cord: 112 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0
gnomAD missense Z: -0.75
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VAT1L as an antibody target. Whether an autoantibody or antibody against VAT1L could matter depends on whether native VAT1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VAT1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VAT1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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