Seroatlas · Human Serome Atlas

DHRS9

Dehydrogenase/reductase SDR family member 9

Also known as: 3alpha-HSD, DHRS9_HUMAN, RDH15, RDHL, RETSDR8, SDR9C4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BPW9
Gene
DHRS9
Ensembl
ENSG00000073737
Chromosome
2
Canonical length
319 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Quaternary structure
Homotetramer

OverviewNCBI Gene

This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. This protein demonstrates oxidoreductase activity toward hydroxysteroids and is able to convert 3-alpha-tetrahydroprogesterone to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone in the cytoplasm, and may additionally function as a transcriptional repressor in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Canonical amino-acid sequenceUniProt

319 residues, UniProt reviewed canonical sequence.

>Q9BPW9|DHRS9
     1  MLFWVLGLLI LCGFLWTRKG KLKIEDITDK YIFITGCDSG FGNLAARTFD KKGFHVIAAC
    61  LTESGSTALK AETSERLRTV LLDVTDPENV KRTAQWVKNQ VGEKGLWGLI NNAGVPGVLA
   121  PTDWLTLEDY REPIEVNLFG LISVTLNMLP LVKKAQGRVI NVSSVGGRLA IVGGGYTPSK
   181  YAVEGFNDSL RRDMKAFGVH VSCIEPGLFK TNLADPVKVI EKKLAIWEQL SPDIKQQYGE
   241  GYIEKSLDKL KGNKSYVNMD LSPVVECMDH ALTSLFPKTH YAAGKDAKIF WIPLSHMPAA
   301  LQDFLLLKQK AELANPKAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DHRS9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
66 nTPM

Expression across tissuesHPA

Tissue

  • colon: 66 nTPM
  • heart muscle: 50 nTPM
  • rectum: 43 nTPM
  • esophagus: 26 nTPM
  • tonsil: 25 nTPM
  • lymph node: 19 nTPM

Single-cell type

  • syncytiotrophoblasts: 577 nCPM
  • esophageal apical cells: 427 nCPM
  • colonocytes: 385 nCPM
  • respiratory secretory cells: 186 nCPM
  • foveolar cells: 162 nCPM
  • early spermatids: 159 nCPM

Immune cell

  • basophil: 259 nTPM
  • eosinophil: 100 nTPM
  • neutrophil: 78 nTPM
  • intermediate monocyte: 25 nTPM
  • myeloid DC: 22 nTPM
  • classical monocyte: 21 nTPM

Brain region

  • white matter: 7.1 nTPM
  • pons: 6.1 nTPM
  • medulla oblongata: 6 nTPM
  • spinal cord: 5.6 nTPM
  • thalamus: 4.3 nTPM
  • midbrain: 4.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.62
gnomAD pLI
0
gnomAD missense Z
-1.05
DepMap mean gene effect
0.14
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DHRS9 as an antibody target. Whether an autoantibody or antibody against DHRS9 could matter depends on whether native DHRS9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DHRS9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DHRS9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DHRS9. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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