Seroatlas · Human Serome Atlas

DHRS4L2

Dehydrogenase/reductase SDR family member 4-like 2

Also known as: DR4L2_HUMAN, SDR25C3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PKH6
Gene: DHRS4L2
Ensembl: ENSG00000187630
Chromosome: 14
Canonical length: 232 aa
Protein class: Metabolic proteins, Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted - unknown location

OverviewNCBI Gene

This gene encodes a member of the short chain dehydrogenase reductase family. The encoded protein may be an NADPH dependent retinol oxidoreductase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]

Canonical amino-acid sequenceUniProt

232 residues, UniProt reviewed canonical sequence.

>Q6PKH6|DHRS4L2
     1  MQMARLLGLC AWARKSVRMA SSRMTRRDPL TNKVALVTAS TDGIGFAIAR RLAQDRAHVV
    61  VSSRKQQNVD QAVATLQGEG LSVTGTVCHV GKAEDRERLV AMAVKLHGGI DILVSNAAVN
   121  PFFGSLMDVT EEVWDKTLDI NVKAPALMTK AVVPEMEKRG GGSVVIVSSI AAFSPSPGFS
   181  PYNVSKTALL GLNNTLAIEL APRNIRVNCL HLDLSRLASA GCSGWTRKKR KA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DHRS4L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 123 nTPM

Expression across tissuesHPA

Tissue

liver: 123 nTPM
kidney: 99 nTPM
skeletal muscle: 49 nTPM
testis: 44 nTPM
heart muscle: 42 nTPM
adrenal gland: 38 nTPM

Single-cell type

proximal tubule cells: 27 nCPM
late primary spermatocytes: 17 nCPM
distal convoluted tubule cells: 16 nCPM
late spermatids: 14 nCPM
loop of henle epithelial cells: 13 nCPM
papillary tip epithelial cells: 12 nCPM

Immune cell

classical monocyte: 54 nTPM
intermediate monocyte: 46 nTPM
myeloid DC: 45 nTPM
plasmacytoid DC: 36 nTPM
total PBMC: 32 nTPM
non-classical monocyte: 29 nTPM

Brain region

choroid plexus: 22 nTPM
medulla oblongata: 20 nTPM
thalamus: 20 nTPM
white matter: 20 nTPM
basal ganglia: 19 nTPM
pons: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.58
gnomAD pLI: 0
gnomAD missense Z: -2.13
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

retinal metabolic process

Molecular functions

carbonyl reductase (NADPH) activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DHRS4L2 as an antibody target. Whether an autoantibody or antibody against DHRS4L2 could matter depends on whether native DHRS4L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DHRS4L2 is annotated as secreted, so native DHRS4L2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label DHRS4L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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