FAR2

Protein identityUniProt · HPA

UniProt accession

Q96K12

Gene

FAR2

Ensembl

ENSG00000064763

Chromosome

12

Canonical length

515 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Nucleoli,Golgi apparatus

OverviewNCBI Gene

This gene belongs to the short chain dehydrogenase/reductase superfamily. It encodes a reductase enzyme involved in the first step of wax biosynthesis wherein fatty acids are converted to fatty alcohols. The encoded peroxisomal protein utilizes saturated fatty acids of 16 or 18 carbons as preferred substrates. Alternatively spliced transcript variants have been observed for this gene. Related pseudogenes have been identified on chromosomes 2, 14 and 22. [provided by RefSeq, Nov 2012]

Canonical amino-acid sequenceUniProt

515 residues, UniProt reviewed canonical sequence.

>Q96K12|FAR2
     1  MSTIAAFYGG KSILITGATG FLGKVLMEKL FRTSPDLKVI YILVRPKAGQ TLQQRVFQIL
    61  DSKLFEKVKE VCPNVHEKIR AIYADLNQND FAISKEDMQE LLSCTNIIFH CAATVRFDDT
   121  LRHAVQLNVT ATRQLLLMAS QMPKLEAFIH ISTAYSNCNL KHIDEVIYPC PVEPKKIIDS
   181  LEWLDDAIID EITPKLIRDW PNIYTYTKAL GEMVVQQESR NLNIAIIRPS IVGATWQEPF
   241  PGWVDNINGP NGIIIATGKG FLRAIKATPM AVADVIPVDT VVNLMLAVGW YTAVHRPKST
   301  LVYHITSGNM NPCNWHKMGV QVLATFEKIP FERPFRRPNA NFTSNSFTSQ YWNAVSHRAP
   361  AIIYDCYLRL TGRKPRMTKL MNRLLRTVSM LEYFINRSWE WSTYNTEMLM SELSPEDQRV
   421  FNFDVRQLNW LEYIENYVLG VKKYLLKEDM AGIPKAKQRL KRLRNIHYLF NTALFLIAWR
   481  LLIARSQMAR NVWFFIVSFC YKFLSYFRAS STLKV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.25

Highest tissue expression

21 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FAR2.

Disease | ImmuneIEDB

Conditions an epitope on FAR2 was assayed in.

• viral infectious disease T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.43

gnomAD pLI

0.56

gnomAD missense Z

1.7

DepMap mean gene effect

-0.26

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• long-chain fatty-acyl-CoA metabolic process
• wax biosynthetic process

Molecular functions

• alcohol-forming long-chain fatty acyl-CoA reductase activity
• alcohol-forming very long-chain fatty acyl-CoA reductase activity
• oxidoreductase activity

Cellular components

• peroxisomal membrane
• peroxisome

Protein domainsUniProt · Pfam · InterPro

• Fatty acyl-CoA reductase-like, NAD-binding domain
• Fatty acyl-CoA reductase
• Fatty acyl-CoA reductase, C-terminal
• NAD(P)-binding domain superfamily
• Male sterility protein
• Male sterility protein

KeywordsUniProt

• Lipid biosynthesis
• Lipid metabolism
• Membrane
• NADP
• Oxidoreductase
• Peroxisome
• Transmembrane
• Transmembrane helix