Seroatlas · Human Serome Atlas

HSD17B7

3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7

Also known as: DHB7_HUMAN, PRAP, SDR37C1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P56937
Gene
HSD17B7
Ensembl
ENSG00000132196
Chromosome
1
Canonical length
341 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

HSD17B7 encodes an enzyme that functions both as a 17-beta-hydroxysteroid dehydrogenase (EC 1.1.1.62) in the biosynthesis of sex steroids and as a 3-ketosteroid reductase (EC 1.1.1.270) in the biosynthesis of cholesterol (Marijanovic et al., 2003 [PubMed 12829805]).[supplied by OMIM, May 2010]

Canonical amino-acid sequenceUniProt

341 residues, UniProt reviewed canonical sequence.

>P56937|HSD17B7
     1  MRKVVLITGA SSGIGLALCK RLLAEDDELH LCLACRNMSK AEAVCAALLA SHPTAEVTIV
    61  QVDVSNLQSV FRASKELKQR FQRLDCIYLN AGIMPNPQLN IKALFFGLFS RKVIHMFSTA
   121  EGLLTQGDKI TADGLQEVFE TNVFGHFILI RELEPLLCHS DNPSQLIWTS SRSARKSNFS
   181  LEDFQHSKGK EPYSSSKYAT DLLSVALNRN FNQQGLYSNV ACPGTALTNL TYGILPPFIW
   241  TLLMPAILLL RFFANAFTLT PYNGTEALVW LFHQKPESLN PLIKYLSATT GFGRNYIMTQ
   301  KMDLDEDTAE KFYQKLLELE KHIRVTIQKT DNQARLSGSC L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSD17B7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
65 nTPM

Expression across tissuesHPA

Tissue

  • liver: 65 nTPM
  • adrenal gland: 26 nTPM
  • pituitary gland: 15 nTPM
  • choroid plexus: 14 nTPM
  • spinal cord: 13 nTPM
  • esophagus: 13 nTPM

Single-cell type

  • epididymal principal cells: 247 nCPM
  • epididymal efferent duct ciliated cells: 105 nCPM
  • breast lactating cells: 87 nCPM
  • adrenal cortex cells: 55 nCPM
  • alveolar cells type 2: 43 nCPM
  • epididymal efferent duct absorptive cells: 39 nCPM

Immune cell

  • basophil: 24 nTPM
  • T-reg: 18 nTPM
  • MAIT T-cell: 15 nTPM
  • memory CD8 T-cell: 14 nTPM
  • gdT-cell: 14 nTPM
  • naive CD4 T-cell: 13 nTPM

Brain region

  • midbrain: 12 nTPM
  • pons: 12 nTPM
  • medulla oblongata: 11 nTPM
  • white matter: 11 nTPM
  • hypothalamus: 11 nTPM
  • cerebral cortex: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.16
gnomAD pLI
0
gnomAD missense Z
0.59
DepMap mean gene effect
-0.19
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSD17B7 as an antibody target. Whether an autoantibody or antibody against HSD17B7 could matter depends on whether native HSD17B7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSD17B7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HSD17B7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HSD17B7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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