Seroatlas · Human Serome Atlas

HTATIP2

Protein HTATIP2

Also known as: CC3, FLJ26963, HTAI2_HUMAN, SDR44U1, TIP30

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BUP3
Gene: HTATIP2
Ensembl: ENSG00000109854
Chromosome: 11
Canonical length: 242 aa
Protein class: Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables protein serine/threonine kinase activity. Involved in import into nucleus and regulation of angiogenesis. Acts upstream of or within positive regulation of programmed cell death; positive regulation of transcription by RNA polymerase II; and protein autophosphorylation. Located in cytosol and nuclear envelope. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

242 residues, UniProt reviewed canonical sequence.

>Q9BUP3|HTATIP2
     1  MAETEALSKL REDFRMQNKS VFILGASGET GRVLLKEILE QGLFSKVTLI GRRKLTFDEE
    61  AYKNVNQEVV DFEKLDDYAS AFQGHDVGFC CLGTTRGKAG AEGFVRVDRD YVLKSAELAK
   121  AGGCKHFNLL SSKGADKSSN FLYLQVKGEV EAKVEELKFD RYSVFRPGVL LCDRQESRPG
   181  EWLVRKFFGS LPDSWASGHS VPVVTVVRAM LNNVVRPRDK QMELLENKAI HDLGKAHGSL
   241  KP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HTATIP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 128 nTPM

Expression across tissuesHPA

Tissue

duodenum: 128 nTPM
small intestine: 114 nTPM
liver: 91 nTPM
colon: 83 nTPM
rectum: 76 nTPM
stomach: 71 nTPM

Single-cell type

platelets: 296 nCPM
enterocytes: 258 nCPM
esophageal suprabasal cells: 179 nCPM
extravillous trophoblasts: 161 nCPM
colonocytes: 160 nCPM
salivary duct cells: 136 nCPM

Immune cell

neutrophil: 306 nTPM
basophil: 235 nTPM
eosinophil: 172 nTPM
T-reg: 141 nTPM
non-classical monocyte: 136 nTPM
classical monocyte: 134 nTPM

Brain region

white matter: 52 nTPM
basal ganglia: 33 nTPM
choroid plexus: 31 nTPM
medulla oblongata: 30 nTPM
cerebral cortex: 30 nTPM
pons: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.9
gnomAD pLI: 0
gnomAD missense Z: 0.55
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein serine/threonine kinase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HTATIP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HTATIP2 as an antibody target. Whether an autoantibody or antibody against HTATIP2 could matter depends on whether native HTATIP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HTATIP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HTATIP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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