Seroatlas · Human Serome Atlas

PECR

Peroxisomal trans-2-enoyl-CoA reductase

Also known as: HSA250303, PECR_HUMAN, SDR29C1, TERP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BY49
Gene: PECR
Ensembl: ENSG00000115425
Chromosome: 2
Canonical length: 303 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Peroxisomes

OverviewNCBI Gene

Enables signaling receptor binding activity and trans-2-enoyl-CoA reductase (NADPH) activity. Involved in phytol metabolic process. Located in peroxisome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

303 residues, UniProt reviewed canonical sequence.

>Q9BY49|PECR
     1  MASWAKGRSY LAPGLLQGQV AIVTGGATGI GKAIVKELLE LGSNVVIASR KLERLKSAAD
    61  ELQANLPPTK QARVIPIQCN IRNEEEVNNL VKSTLDTFGK INFLVNNGGG QFLSPAEHIS
   121  SKGWHAVLET NLTGTFYMCK AVYSSWMKEH GGSIVNIIVP TKAGFPLAVH SGAARAGVYN
   181  LTKSLALEWA CSGIRINCVA PGVIYSQTAV ENYGSWGQSF FEGSFQKIPA KRIGVPEEVS
   241  SVVCFLLSPA ASFITGQSVD VDGGRSLYTH SYEVPDHDNW PKGAGDLSVV KKMKETFKEK
   301  AKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PECR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 150 nTPM

Expression across tissuesHPA

Tissue

liver: 150 nTPM
kidney: 32 nTPM
duodenum: 24 nTPM
adipose tissue: 24 nTPM
small intestine: 19 nTPM
thyroid gland: 15 nTPM

Single-cell type

adipocytes: 371 nCPM
hepatocytes: 135 nCPM
neutrophil progenitors: 117 nCPM
neutrophils: 97 nCPM
renal collecting duct principal cells: 93 nCPM
proximal tubule cells: 81 nCPM

Immune cell

T-reg: 17 nTPM
NK-cell: 9.6 nTPM
naive CD4 T-cell: 9.1 nTPM
memory CD4 T-cell: 8.7 nTPM
MAIT T-cell: 7.7 nTPM
memory CD8 T-cell: 7.4 nTPM

Brain region

choroid plexus: 13 nTPM
cerebellum: 8 nTPM
white matter: 7.5 nTPM
medulla oblongata: 7 nTPM
pons: 7 nTPM
midbrain: 6.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0
gnomAD missense Z: 0.05
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PECR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PEX5

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PECR as an antibody target. Whether an autoantibody or antibody against PECR could matter depends on whether native PECR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PECR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PECR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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