Seroatlas · Human Serome Atlas

NMRAL1

NmrA-like family domain-containing protein 1

Also known as: FLJ25918, HSCARG, NMRL1_HUMAN, SDR48A1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HBL8
Gene: NMRAL1
Ensembl: ENSG00000153406
Chromosome: 16
Canonical length: 299 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes an NADPH sensor protein that preferentially binds to NADPH. The encoded protein also negatively regulates the activity of NF-kappaB in a ubiquitylation-dependent manner. It plays a key role in cellular antiviral response by negatively regulating the interferon response factor 3-mediated expression of interferon beta. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Canonical amino-acid sequenceUniProt

299 residues, UniProt reviewed canonical sequence.

>Q9HBL8|NMRAL1
     1  MVDKKLVVVF GGTGAQGGSV ARTLLEDGTF KVRVVTRNPR KKAAKELRLQ GAEVVQGDQD
    61  DQVIMELALN GAYATFIVTN YWESCSQEQE VKQGKLLADL ARRLGLHYVV YSGLENIKKL
   121  TAGRLAAAHF DGKGEVEEYF RDIGVPMTSV RLPCYFENLL SHFLPQKAPD GKSYLLSLPT
   181  GDVPMDGMSV SDLGPVVLSL LKMPEKYVGQ NIGLSTCRHT AEEYAALLTK HTRKVVHDAK
   241  MTPEDYEKLG FPGARDLANM FRFYALRPDR DIELTLRLNP KALTLDQWLE QHKGDFNLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NMRAL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

liver: 58 nTPM
basal ganglia: 45 nTPM
pancreas: 45 nTPM
spinal cord: 44 nTPM
stomach: 43 nTPM
midbrain: 42 nTPM

Single-cell type

gastric chief cells: 59 nCPM
extravillous trophoblasts: 59 nCPM
cytotrophoblasts: 56 nCPM
epididymal principal cells: 53 nCPM
migrating cytotrophoblasts: 47 nCPM
hofbauer cells: 41 nCPM

Immune cell

gdT-cell: 61 nTPM
classical monocyte: 59 nTPM
memory CD8 T-cell: 57 nTPM
myeloid DC: 54 nTPM
total PBMC: 54 nTPM
plasmacytoid DC: 53 nTPM

Brain region

white matter: 25 nTPM
medulla oblongata: 24 nTPM
cerebral cortex: 23 nTPM
pons: 23 nTPM
basal ganglia: 23 nTPM
cerebellum: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.33
gnomAD pLI: 0
gnomAD missense Z: -0.73
DepMap mean gene effect: -0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

identical protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

NAD(P)-binding domain superfamily
NmrA-like domain
NmrA-like oxidoreductase
NmrA-like family

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NMRAL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NMRAL1 as an antibody target. Whether an autoantibody or antibody against NMRAL1 could matter depends on whether native NMRAL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NMRAL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NMRAL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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