Seroatlas · Human Serome Atlas

TDH

Inactive L-threonine 3-dehydrogenase, mitochondrial

Also known as: TDH_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IZJ6
Gene: TDH
Canonical length: 230 aa

OverviewNCBI Gene

No narrative summary is available for TDH in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

230 residues, UniProt reviewed canonical sequence.

>Q8IZJ6|TDH
     1  MLFIRMLRRA GQSPACGCWT PVLPVRFLGI SPRQIPADAN FHSASFSDTD HPRVLITGAL
    61  GQLGVGLANL LRKRFGKDSV ILSDIRKPPD HVFHSGPFIY SDILDYKNLR EIVVNNRITW
   121  LFHYSALLSA FGEANVSLAR AVNITGLHNI LDVAAEHNLQ LFVPSTIGAF GPTSPRNPTP
   181  DLCIQRPRTI YGVSKVHAEL MGETMQSRFS MMPQSMANSS ATWKPARDCP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TDH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

mitochondrion

Protein domainsUniProt · Pfam · InterPro

NAD-dependent epimerase/dehydratase
NAD(P)-binding domain superfamily
NAD dependent epimerase/dehydratase family
NAD(P)-dependent epimerase/dehydratase

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TDH as an antibody target. Whether an autoantibody or antibody against TDH could matter depends on whether native TDH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TDH is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TDH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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