Seroatlas · Human Serome Atlas

KCNT2

Potassium channel subfamily T member 2

Also known as: KCa4.2, KCNT2_HUMAN, SLICK, SLO2.1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UVM3
Gene: KCNT2
Ensembl: ENSG00000162687
Chromosome: 1
Canonical length: 1135 aa
Protein class: Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels
Subcellular location: Vesicles
Quaternary structure: Homotetramer

OverviewNCBI Gene

Enables chloride-activated potassium channel activity and intracellular sodium-activated potassium channel activity. Involved in potassium ion export across plasma membrane. Located in plasma membrane. Implicated in developmental and epileptic encephalopathy 57. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1135 residues, UniProt reviewed canonical sequence.

>Q6UVM3|KCNT2
     1  MVDLESEVPP LPPRYRFRDL LLGDQGWQND DRVQVEFYMN ENTFKERLKL FFIKNQRSSL
    61  RIRLFNFSLK LLSCLLYIIR VLLENPSQGN EWSHIFWVNR SLPLWGLQVS VALISLFETI
   121  LLGYLSYKGN IWEQILRIPF ILEIINAVPF IISIFWPSLR NLFVPVFLNC WLAKHALENM
   181  INDLHRAIQR TQSAMFNQVL ILISTLLCLI FTCICGIQHL ERIGKKLNLF DSLYFCIVTF
   241  STVGFGDVTP ETWSSKLFVV AMICVALVVL PIQFEQLAYL WMERQKSGGN YSRHRAQTEK
   301  HVVLCVSSLK IDLLMDFLNE FYAHPRLQDY YVVILCPTEM DVQVRRVLQI PMWSQRVIYL
   361  QGSALKDQDL LRAKMDDAEA CFILSSRCEV DRTSSDHQTI LRAWAVKDFA PNCPLYVQIL
   421  KPENKFHIKF ADHVVCEEEF KYAMLALNCI CPATSTLITL LVHTSRGQEG QQSPEQWQKM
   481  YGRCSGNEVY HIVLEESTFF AEYEGKSFTY ASFHAHKKFG VCLIGVRRED NKNILLNPGP
   541  RYIMNSTDIC FYINITKEEN SAFKNQDQQR KSNVSRSFYH GPSRLPVHSI IASMGTVAID
   601  LQDTSCRSAS GPTLSLPTEG SKEIRRPSIA PVLEVADTSS IQTCDLLSDQ SEDETTPDEE
   661  MSSNLEYAKG YPPYSPYIGS SPTFCHLLHE KVPFCCLRLD KSCQHNYYED AKAYGFKNKL
   721  IIVAAETAGN GLYNFIVPLR AYYRPKKELN PIVLLLDNPP DMHFLDAICW FPMVYYMVGS
   781  IDNLDDLLRC GVTFAANMVV VDKESTMSAE EDYMADAKTI VNVQTLFRLF SSLSIITELT
   841  HPANMRFMQF RAKDCYSLAL SKLEKKERER GSNLAFMFRL PFAAGRVFSI SMLDTLLYQS
   901  FVKDYMISIT RLLLGLDTTP GSGFLCSMKI TADDLWIRTY ARLYQKLCSS TGDVPIGIYR
   961  TESQKLTTSE SQISISVEEW EDTKDSKEQG HHRSNHRNST SSDQSDHPLL RRKSMQWARR
  1021  LSRKGPKHSG KTAEKITQQR LNLYRRSERQ ELAELVKNRM KHLGLSTVGY DEMNDHQSTL
  1081  SYILINPSPD TRIELNDVVY LIRPDPLAYL PNSEPSRRNS ICNVTGQDSR EETQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 3.5 nTPM

Expression across tissuesHPA

Tissue

ovary: 3.5 nTPM
blood vessel: 2.9 nTPM
liver: 2.6 nTPM
cerebral cortex: 2 nTPM
lung: 1.7 nTPM
heart muscle: 1.6 nTPM

Single-cell type

epicardial cells: 1,151 nCPM
mesothelial cells: 684 nCPM
gonadotrophs: 603 nCPM
bergmann glia: 583 nCPM
thyrotrophs: 492 nCPM
oligodendrocyte progenitor cells: 388 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 15 nTPM
hippocampal formation: 13 nTPM
basal ganglia: 11 nTPM
cerebral cortex: 11 nTPM
white matter: 8.3 nTPM
spinal cord: 7.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KCNT2.

Disease | AllUniProt

Conditions KCNT2 is implicated in, by any mechanism.

Developmental and epileptic encephalopathy 57 (DEE57) MIM:617771

Disease | GeneticClinVar

17 pathogenic / likely-pathogenic of 314 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Developmental and epileptic encephalopathy, 57
KCNT2-related disorder
Seizure
See cases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.37
gnomAD pLI: 0.04
gnomAD missense Z: 3.56
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

intracellular sodium-activated potassium channel activity
outward rectifier potassium channel activity
chloride-activated potassium channel activity

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KCNT2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

KCNT1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNT2 as an antibody target. Whether an autoantibody or antibody against KCNT2 could matter depends on whether native KCNT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNT2 is annotated at the cell surface, where native KCNT2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCNT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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