Seroatlas · Human Serome Atlas

DHRS12

Dehydrogenase/reductase SDR family member 12

Also known as: DHR12_HUMAN, FLJ13639, SDR40C1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0PJE2
Gene: DHRS12
Ensembl: ENSG00000102796
Chromosome: 13
Canonical length: 317 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Vesicles

OverviewNCBI Gene

This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members in this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

317 residues, UniProt reviewed canonical sequence.

>A0PJE2|DHRS12
     1  MSLYRSVVWF AKGLREYTKS GYESACKDFV PHDLEVQIPG RVFLVTGGNS GIGKATALEI
    61  AKRGGTVHLV CRDQAPAEDA RGEIIRESGN QNIFLHIVDL SDPKQIWKFV ENFKQEHKLH
   121  VLINNAGCMV NKRELTEDGL EKNFAANTLG VYILTTGLIP VLEKEHDPRV ITVSSGGMLV
   181  QKLNTNDLQS ERTPFDGTMV YAQNKRQQVV LTERWAQGHP AIHFSSMHPG WADTPGVRQA
   241  MPGFHARFGD RLRSEAQGAD TMLWLALSSA AAAQPSGRFF QDRKPVSTHL PLATASSSPA
   301  EEEKLIEILE QLAQTFK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DHRS12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.22
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

pancreas: 47 nTPM
liver: 18 nTPM
adipose tissue: 16 nTPM
salivary gland: 16 nTPM
skeletal muscle: 15 nTPM
kidney: 14 nTPM

Single-cell type

late spermatids: 58 nCPM
pancreatic acinar cells: 23 nCPM
oocytes: 23 nCPM
parietal cells: 23 nCPM
epididymal efferent duct absorptive cells: 19 nCPM
early spermatids: 18 nCPM

Immune cell

neutrophil: 106 nTPM
MAIT T-cell: 33 nTPM
memory CD4 T-cell: 25 nTPM
T-reg: 24 nTPM
non-classical monocyte: 23 nTPM
memory CD8 T-cell: 22 nTPM

Brain region

cerebellum: 22 nTPM
white matter: 21 nTPM
amygdala: 20 nTPM
spinal cord: 20 nTPM
medulla oblongata: 19 nTPM
basal ganglia: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0
gnomAD missense Z: 0.25
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

oxidoreductase activity

Protein domainsUniProt · Pfam · InterPro

Short-chain dehydrogenase/reductase SDR
NAD(P)-binding domain superfamily
short chain dehydrogenase
Short-chain dehydrogenases/reductases member 12

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DHRS12 as an antibody target. Whether an autoantibody or antibody against DHRS12 could matter depends on whether native DHRS12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DHRS12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DHRS12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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