Seroatlas · Human Serome Atlas

AHCYL1

S-adenosylhomocysteine hydrolase-like protein 1

Also known as: IRBIT, PPP1R78, SAHH2_HUMAN, XPVKONA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43865
Gene
AHCYL1
Ensembl
ENSG00000168710
Chromosome
1
Canonical length
530 aa
Protein class
Metabolic proteins, Predicted intracellular proteins, Transporters
Subcellular location
Cytosol

OverviewNCBI Gene

The protein encoded by this gene interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

Canonical amino-acid sequenceUniProt

530 residues, UniProt reviewed canonical sequence.

>O43865|AHCYL1
     1  MSMPDAMPLP GVGEELKQAK EIEDAEKYSF MATVTKAPKK QIQFADDMQE FTKFPTKTGR
    61  RSLSRSISQS STDSYSSAAS YTDSSDDEVS PREKQQTNSK GSSNFCVKNI KQAEFGRREI
   121  EIAEQDMSAL ISLRKRAQGE KPLAGAKIVG CTHITAQTAV LIETLCALGA QCRWSACNIY
   181  STQNEVAAAL AEAGVAVFAW KGESEDDFWW CIDRCVNMDG WQANMILDDG GDLTHWVYKK
   241  YPNVFKKIRG IVEESVTGVH RLYQLSKAGK LCVPAMNVND SVTKQKFDNL YCCRESILDG
   301  LKRTTDVMFG GKQVVVCGYG EVGKGCCAAL KALGAIVYIT EIDPICALQA CMDGFRVVKL
   361  NEVIRQVDVV ITCTGNKNVV TREHLDRMKN SCIVCNMGHS NTEIDVTSLR TPELTWERVR
   421  SQVDHVIWPD GKRVVLLAEG RLLNLSCSTV PTFVLSITAT TQALALIELY NAPEGRYKQD
   481  VYLLPKKMDE YVASLHLPSF DAHLTELTDD QAKYLGLNKN GPFKPNYYRY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AHCYL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
236 nTPM

Expression across tissuesHPA

Tissue

  • midbrain: 236 nTPM
  • choroid plexus: 223 nTPM
  • basal ganglia: 204 nTPM
  • cerebral cortex: 196 nTPM
  • amygdala: 186 nTPM
  • hypothalamus: 175 nTPM

Single-cell type

  • bergmann glia: 561 nCPM
  • astrocytes: 530 nCPM
  • endometrial ciliated cells: 311 nCPM
  • pancreatic duct cells: 291 nCPM
  • somatotrophs: 286 nCPM
  • endometrial luminal cells: 248 nCPM

Immune cell

  • intermediate monocyte: 5.4 nTPM
  • classical monocyte: 5 nTPM
  • T-reg: 5 nTPM
  • neutrophil: 4.7 nTPM
  • eosinophil: 4.6 nTPM
  • naive B-cell: 4.4 nTPM

Brain region

  • medulla oblongata: 558 nTPM
  • spinal cord: 499 nTPM
  • thalamus: 480 nTPM
  • hypothalamus: 479 nTPM
  • midbrain: 458 nTPM
  • white matter: 451 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.28
gnomAD pLI
0.99
gnomAD missense Z
4.02
DepMap mean gene effect
-0.41
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AHCYL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AHCYL1 as an antibody target. Whether an autoantibody or antibody against AHCYL1 could matter depends on whether native AHCYL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AHCYL1 is annotated at the cell surface, where native AHCYL1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label AHCYL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AHCYL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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