Seroatlas · Human Serome Atlas

HSD17B2

17-beta-hydroxysteroid dehydrogenase type 2

Also known as: DHB2_HUMAN, HSD17, SDR9C2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P37059
Gene: HSD17B2
Ensembl: ENSG00000086696
Chromosome: 16
Canonical length: 387 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Endoplasmic reticulum
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity and testosterone dehydrogenase (NAD+) activity. Involved in androgen metabolic process; estrogen biosynthetic process; and response to retinoic acid. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

387 residues, UniProt reviewed canonical sequence.

>P37059|HSD17B2
     1  MSTFFSDTAW ICLAVPTVLC GTVFCKYKKS SGQLWSWMVC LAGLCAVCLL ILSPFWGLIL
    61  FSVSCFLMYT YLSGQELLPV DQKAVLVTGG DCGLGHALCK YLDELGFTVF AGVLNENGPG
   121  AEELRRTCSP RLSVLQMDIT KPVQIKDAYS KVAAMLQDRG LWAVINNAGV LGFPTDGELL
   181  LMTDYKQCMA VNFFGTVEVT KTFLPLLRKS KGRLVNVSSM GGGAPMERLA SYGSSKAAVT
   241  MFSSVMRLEL SKWGIKVASI QPGGFLTNIA GTSDKWEKLE KDILDHLPAE VQEDYGQDYI
   301  LAQRNFLLLI NSLASKDFSP VLRDIQHAIL AKSPFAYYTP GKGAYLWICL AHYLPIGIYD
   361  YFAKRHFGQD KPMPRALRMP NYKKKAT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSD17B2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 404 nTPM

Expression across tissuesHPA

Tissue

duodenum: 404 nTPM
placenta: 359 nTPM
liver: 204 nTPM
small intestine: 178 nTPM
urinary bladder: 74 nTPM
colon: 70 nTPM

Single-cell type

enterocytes: 491 nCPM
breast lactating cells: 432 nCPM
cholangiocytes: 263 nCPM
endometrial glandular cells: 243 nCPM
hepatocytes: 235 nCPM
colonocytes: 216 nCPM

Immune cell

neutrophil: 0.5 nTPM
basophil: 0.3 nTPM
plasmacytoid DC: 0.2 nTPM
classical monocyte: 0.1 nTPM
naive B-cell: 0.1 nTPM
NK-cell: 0.1 nTPM

Brain region

cerebellum: 6 nTPM
cerebral cortex: 5.2 nTPM
amygdala: 5.1 nTPM
basal ganglia: 4.9 nTPM
hippocampal formation: 4.9 nTPM
hypothalamus: 4.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.73
gnomAD pLI: 0
gnomAD missense Z: -1.57
DepMap mean gene effect: 0.17
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

endoplasmic reticulum membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSD17B2 as an antibody target. Whether an autoantibody or antibody against HSD17B2 could matter depends on whether native HSD17B2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSD17B2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HSD17B2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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