Seroatlas · Human Serome Atlas

SDR16C5

Epidermal retinol dehydrogenase 2

Also known as: EPHD-2, RDH-E2, RDHE2, RDHE2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N3Y7
Gene: SDR16C5
Ensembl: ENSG00000170786
Chromosome: 8
Canonical length: 309 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the short-chain alcohol dehydrogenase/reductase superfamily of proteins and is involved in the oxidation of retinol to retinaldehyde. The encoded protein is associated with the endoplasmic reticulum and is predicted to contain three transmembrane helices, suggesting that it is an integral membrane protein. It recognizes all-trans-retinol and all-trans-retinaldehyde as substrates and exhibits a strong preference for NAD(+)/NADH as cofactors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

309 residues, UniProt reviewed canonical sequence.

>Q8N3Y7|SDR16C5
     1  MSFNLQSSKK LFIFLGKSLF SLLEAMIFAL LPKPRKNVAG EIVLITGAGS GLGRLLALQF
    61  ARLGSVLVLW DINKEGNEET CKMAREAGAT RVHAYTCDCS QKEGVYRVAD QVKKEVGDVS
   121  ILINNAGIVT GKKFLDCPDE LMEKSFDVNF KAHLWTYKAF LPAMIANDHG HLVCISSSAG
   181  LSGVNGLADY CASKFAAFGF AESVFVETFV QKQKGIKTTI VCPFFIKTGM FEGCTTGCPS
   241  LLPILEPKYA VEKIVEAILQ EKMYLYMPKL LYFMMFLKSF LPLKTGLLIA DYLGILHAMD
   301  GFVDQKKKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SDR16C5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 48 nTPM

Expression across tissuesHPA

Tissue

skin: 48 nTPM
esophagus: 38 nTPM
lung: 27 nTPM
tonsil: 21 nTPM
vagina: 19 nTPM
stomach: 17 nTPM

Single-cell type

esophageal apical cells: 824 nCPM
alveolar cells type 2: 654 nCPM
esophageal suprabasal cells: 263 nCPM
alveolar cells type 1: 231 nCPM
suprabasal keratinocytes: 221 nCPM
transitional alveolar cells: 169 nCPM

Immune cell

memory B-cell: 4.7 nTPM
naive B-cell: 2.3 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

pons: 9.6 nTPM
cerebral cortex: 5.7 nTPM
thalamus: 5.4 nTPM
medulla oblongata: 5.3 nTPM
midbrain: 3.4 nTPM
white matter: 3.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.88
gnomAD pLI: 0.01
gnomAD missense Z: -0.26
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SDR16C5 as an antibody target. Whether an autoantibody or antibody against SDR16C5 could matter depends on whether native SDR16C5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SDR16C5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SDR16C5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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