CRYL1

Protein identityUniProt · HPA

UniProt accession

Q9Y2S2

Gene

CRYL1

Ensembl

ENSG00000165475

Chromosome

13

Canonical length

319 aa

Protein class

Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nucleoli,Golgi apparatus,Plasma membrane

Quaternary structure

Homodimer

OverviewNCBI Gene

The uronate cycle functions as an alternative glucose metabolic pathway, accounting for about 5% of daily glucose catabolism. The product of this gene catalyzes the dehydrogenation of L-gulonate into dehydro-L-gulonate in the uronate cycle. The enzyme requires NAD(H) as a coenzyme, and is inhibited by inorganic phosphate. A similar gene in the rabbit is thought to serve a structural role in the lens of the eye. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

319 residues, UniProt reviewed canonical sequence.

>Q9Y2S2|CRYL1
     1  MASSAAGCVV IVGSGVIGRS WAMLFASGGF QVKLYDIEQQ QIRNALENIR KEMKLLEQAG
    61  SLKGSLSVEE QLSLISGCPN IQEAVEGAMH IQECVPEDLE LKKKIFAQLD SIIDDRVILS
   121  SSTSCLMPSK LFAGLVHVKQ CIVAHPVNPP YYIPLVELVP HPETAPTTVD RTHALMKKIG
   181  QCPMRVQKEV AGFVLNRLQY AIISEAWRLV EEGIVSPSDL DLVMSEGLGM RYAFIGPLET
   241  MHLNAEGMLS YCDRYSEGIK HVLQTFGPIP EFSRATAEKV NQDMCMKVPD DPEHLAARRQ
   301  WRDECLMRLA KLKSQVQPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRYL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

308 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.06

gnomAD pLI

0

gnomAD missense Z

0.4

DepMap mean gene effect

0.11

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• D-glucuronate catabolic process to D-xylulose 5-phosphate
• fatty acid metabolic process

Molecular functions

• NAD+ binding
• protein homodimerization activity
• L-gulonate 3-dehydrogenase activity

Cellular components

• cytosol
• extracellular exosome

Protein domainsUniProt · Pfam · InterPro

• 3-hydroxyacyl-CoA dehydrogenase, C-terminal
• 3-hydroxyacyl-CoA dehydrogenase, NAD binding
• 3-hydroxyacyl-CoA dehydrogenase, conserved site
• 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
• 6-phosphogluconate dehydrogenase, domain 2
• 3-hydroxyacyl-CoA dehydrogenase
• NAD(P)-binding domain superfamily
• 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
• 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain

KeywordsUniProt

• Acetylation
• Cytoplasm
• NAD
• Oxidoreductase
• Phosphoprotein