Seroatlas · Human Serome Atlas

RDH13

Retinol dehydrogenase 13

Also known as: RDH13_HUMAN, SDR7C3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NBN7
Gene: RDH13
Ensembl: ENSG00000160439
Chromosome: 19
Canonical length: 331 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Mitochondria,Cytosol
Secretome location: Intracellular and membrane

OverviewNCBI Gene

This gene encodes a mitochondrial short-chain dehydrogenase/reductase, which catalyzes the reduction and oxidation of retinoids. The encoded enzyme may function in retinoic acid production and may also protect the mitochondria against oxidative stress. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

Canonical amino-acid sequenceUniProt

331 residues, UniProt reviewed canonical sequence.

>Q8NBN7|RDH13
     1  MSRYLLPLSA LGTVAGAAVL LKDYVTGGAC PSKATIPGKT VIVTGANTGI GKQTALELAR
    61  RGGNIILACR DMEKCEAAAK DIRGETLNHH VNARHLDLAS LKSIREFAAK IIEEEERVDI
   121  LINNAGVMRC PHWTTEDGFE MQFGVNHLGH FLLTNLLLDK LKASAPSRII NLSSLAHVAG
   181  HIDFDDLNWQ TRKYNTKAAY CQSKLAIVLF TKELSRRLQG SGVTVNALHP GVARTELGRH
   241  TGIHGSTFSS TTLGPIFWLL VKSPELAAQP STYLAVAEEL ADVSGKYFDG LKQKAPAPEA
   301  EDEEVARRLW AESARLVGLE APSVREQPLP R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RDH13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

skin: 21 nTPM
esophagus: 20 nTPM
heart muscle: 13 nTPM
vagina: 12 nTPM
parathyroid gland: 12 nTPM
kidney: 11 nTPM

Single-cell type

papillary tip epithelial cells: 47 nCPM
renal connecting tubule cells: 47 nCPM
distal convoluted tubule cells: 44 nCPM
renal collecting duct intercalated cells: 42 nCPM
loop of henle epithelial cells: 35 nCPM
renal collecting duct principal cells: 28 nCPM

Immune cell

naive CD4 T-cell: 8.4 nTPM
gdT-cell: 8.1 nTPM
NK-cell: 7.8 nTPM
MAIT T-cell: 7.7 nTPM
memory CD8 T-cell: 7.5 nTPM
memory CD4 T-cell: 6.2 nTPM

Brain region

midbrain: 15 nTPM
choroid plexus: 14 nTPM
pons: 14 nTPM
thalamus: 14 nTPM
cerebellum: 13 nTPM
hypothalamus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.81
gnomAD pLI: 0
gnomAD missense Z: -0.59
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

all-trans-retinol dehydrogenase (NADP+) activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RDH13 as an antibody target. Whether an autoantibody or antibody against RDH13 could matter depends on whether native RDH13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RDH13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RDH13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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