Seroatlas · Human Serome Atlas

SDR9C7

Short-chain dehydrogenase/reductase family 9C member 7

Also known as: DR9C7_HUMAN, RDHS, SDR-O

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NEX9
Gene: SDR9C7
Ensembl: ENSG00000170426
Chromosome: 12
Canonical length: 313 aa
Protein class: Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a protein with similarity to the short-chain dehydrogenase/reductase (SDR) family but has not been shown to have retinoid or dehydrogenase activities. [provided by RefSeq, Apr 2010]

Canonical amino-acid sequenceUniProt

313 residues, UniProt reviewed canonical sequence.

>Q8NEX9|SDR9C7
     1  MAALTDLSFM YRWFKNCNLV GNLSEKYVFI TGCDSGFGNL LAKQLVDRGM QVLAACFTEE
    61  GSQKLQRDTS YRLQTTLLDV TKSESIKAAA QWVRDKVGEQ GLWALVNNAG VGLPSGPNEW
   121  LTKDDFVKVI NVNLVGLIEV TLHMLPMVKR ARGRVVNMSS SGGRVAVIGG GYCVSKFGVE
   181  AFSDSIRREL YYFGVKVCII EPGNYRTAIL GKENLESRMR KLWERLPQET RDSYGEDYFR
   241  IYTDKLKNIM QVAEPRVRDV INSMEHAIVS RSPRIRYNPG LDAKLLYIPL AKLPTPVTDF
   301  ILSRYLPRPA DSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SDR9C7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 56 nTPM

Expression across tissuesHPA

Tissue

skin: 56 nTPM
cervix: 21 nTPM
vagina: 20 nTPM
esophagus: 14 nTPM
tonsil: 7 nTPM
salivary gland: 3.6 nTPM

Single-cell type

esophageal apical cells: 75 nCPM
suprabasal keratinocytes: 20 nCPM
esophageal suprabasal cells: 16 nCPM
retinal horizontal cells: 4 nCPM
early spermatids: 2.7 nCPM
myonuclei: 1.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1 nTPM
cerebellum: 0.7 nTPM
hippocampal formation: 0.7 nTPM
amygdala: 0.6 nTPM
basal ganglia: 0.6 nTPM
white matter: 0.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SDR9C7.

Disease | AllUniProt

Conditions SDR9C7 is implicated in, by any mechanism.

Ichthyosis, congenital, autosomal recessive 13 (ARCI13) MIM:617574

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 116 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Ichthyosis, congenital, autosomal recessive 13
Lamellar ichthyosis
Congenital ichthyosis of skin
Ichthyosis and erythrokeratoderma

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.88
gnomAD pLI: 0.01
gnomAD missense Z: 0.63
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

all-trans-retinol dehydrogenase (NAD+) activity

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SDR9C7 as an antibody target. Whether an autoantibody or antibody against SDR9C7 could matter depends on whether native SDR9C7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SDR9C7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SDR9C7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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