Seroatlas · Human Serome Atlas

HSD17B11

Estradiol 17-beta-dehydrogenase 11

Also known as: 17-BETA-HSD11, 17-BETA-HSDXI, DHB11_HUMAN, DHRS8, PAN1B, RetSDR2, SDR16C2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NBQ5
Gene: HSD17B11
Ensembl: ENSG00000198189
Chromosome: 4
Canonical length: 300 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Lipid droplets

OverviewNCBI Gene

Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]).[supplied by OMIM, Jun 2009]

Canonical amino-acid sequenceUniProt

300 residues, UniProt reviewed canonical sequence.

>Q8NBQ5|HSD17B11
     1  MKFLLDILLL LPLLIVCSLE SFVKLFIPKR RKSVTGEIVL ITGAGHGIGR LTAYEFAKLK
    61  SKLVLWDINK HGLEETAAKC KGLGAKVHTF VVDCSNREDI YSSAKKVKAE IGDVSILVNN
   121  AGVVYTSDLF ATQDPQIEKT FEVNVLAHFW TTKAFLPAMT KNNHGHIVTV ASAAGHVSVP
   181  FLLAYCSSKF AAVGFHKTLT DELAALQITG VKTTCLCPNF VNTGFIKNPS TSLGPTLEPE
   241  EVVNRLMHGI LTEQKMIFIP SSIAFLTTLE RILPERFLAV LKRKISVKFD AVIGYKMKAQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSD17B11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 272 nTPM

Expression across tissuesHPA

Tissue

small intestine: 272 nTPM
liver: 226 nTPM
duodenum: 204 nTPM
rectum: 137 nTPM
colon: 131 nTPM
bone marrow: 104 nTPM

Single-cell type

neutrophils: 174 nCPM
enterocytes: 148 nCPM
neutrophil progenitors: 88 nCPM
microglia: 68 nCPM
transitional alveolar cells: 49 nCPM
fibro-adipogenic progenitors: 48 nCPM

Immune cell

neutrophil: 772 nTPM
basophil: 594 nTPM
eosinophil: 444 nTPM
classical monocyte: 202 nTPM
total PBMC: 172 nTPM
intermediate monocyte: 143 nTPM

Brain region

white matter: 30 nTPM
medulla oblongata: 25 nTPM
cerebellum: 23 nTPM
spinal cord: 23 nTPM
pons: 21 nTPM
choroid plexus: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.46
gnomAD pLI: 0
gnomAD missense Z: 0.84
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HSD17B11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSD17B11 as an antibody target. Whether an autoantibody or antibody against HSD17B11 could matter depends on whether native HSD17B11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSD17B11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HSD17B11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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