Seroatlas · Human Serome Atlas

DHRS13

Dehydrogenase/reductase SDR family member 13

Also known as: DHR13_HUMAN, MGC23280, SDR7C5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UX07
Gene: DHRS13
Ensembl: ENSG00000167536
Chromosome: 17
Canonical length: 377 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Vesicles
Secretome location: Secreted - unknown location

OverviewNCBI Gene

Predicted to enable oxidoreductase activity. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

377 residues, UniProt reviewed canonical sequence.

>Q6UX07|DHRS13
     1  MEALLLGAGL LLGAYVLVYY NLVKAPPCGG MGNLRGRTAV VTGANSGIGK MTALELARRG
    61  ARVVLACRSQ ERGEAAAFDL RQESGNNEVI FMALDLASLA SVRAFATAFL SSEPRLDILI
   121  HNAGISSCGR TREAFNLLLR VNHIGPFLLT HLLLPCLKAC APSRVVVVAS AAHCRGRLDF
   181  KRLDRPVVGW RQELRAYADT KLANVLFARE LANQLEATGV TCYAAHPGPV NSELFLRHVP
   241  GWLRPLLRPL AWLVLRAPRG GAQTPLYCAL QEGIEPLSGR YFANCHVEEV PPAARDDRAA
   301  HRLWEASKRL AGLGPGEDAE PDEDPQSEDS EAPSSLSTPH PEEPTVSQPY PSPQSSPDLS
   361  KMTHRIQAKV EPEIQLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DHRS13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 39 nTPM
cerebellum: 27 nTPM
choroid plexus: 22 nTPM
liver: 19 nTPM
prostate: 18 nTPM
salivary gland: 12 nTPM

Single-cell type

neutrophils: 82 nCPM
erythrocyte progenitors: 38 nCPM
cytotrophoblasts: 35 nCPM
migrating cytotrophoblasts: 29 nCPM
extravillous trophoblasts: 26 nCPM
basal prostatic cells: 24 nCPM

Immune cell

neutrophil: 56 nTPM
T-reg: 11 nTPM
naive CD4 T-cell: 11 nTPM
memory CD4 T-cell: 11 nTPM
memory CD8 T-cell: 11 nTPM
MAIT T-cell: 10 nTPM

Brain region

cerebellum: 26 nTPM
hypothalamus: 23 nTPM
midbrain: 22 nTPM
pons: 20 nTPM
medulla oblongata: 18 nTPM
thalamus: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0.03
gnomAD missense Z: 0.55
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

oxidoreductase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DHRS13 as an antibody target. Whether an autoantibody or antibody against DHRS13 could matter depends on whether native DHRS13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DHRS13 is annotated as secreted, so native DHRS13 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label DHRS13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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