Seroatlas · Human Serome Atlas

DHRS7

Dehydrogenase/reductase SDR family member 7

Also known as: DHRS7_HUMAN, retDSR4, SDR34C1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y394
Gene
DHRS7
Ensembl
ENSG00000100612
Chromosome
14
Canonical length
339 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Mitochondria

OverviewNCBI Gene

This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members in this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. [provided by RefSeq, Apr 2016]

Canonical amino-acid sequenceUniProt

339 residues, UniProt reviewed canonical sequence.

>Q9Y394|DHRS7
     1  MNWELLLWLL VLCALLLLLV QLLRFLRADG DLTLLWAEWQ GRRPEWELTD MVVWVTGASS
    61  GIGEELAYQL SKLGVSLVLS ARRVHELERV KRRCLENGNL KEKDILVLPL DLTDTGSHEA
   121  ATKAVLQEFG RIDILVNNGG MSQRSLCMDT SLDVYRKLIE LNYLGTVSLT KCVLPHMIER
   181  KQGKIVTVNS ILGIISVPLS IGYCASKHAL RGFFNGLRTE LATYPGIIVS NICPGPVQSN
   241  IVENSLAGEV TKTIGNNGDQ SHKMTTSRCV RLMLISMAND LKEVWISEQP FLLVTYLWQY
   301  MPTWAWWITN KMGKKRIENF KSGVDADSSY FKIFKTKHD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DHRS7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
634 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 634 nTPM
  • prostate: 385 nTPM
  • salivary gland: 299 nTPM
  • parathyroid gland: 213 nTPM
  • stomach: 172 nTPM
  • small intestine: 170 nTPM

Single-cell type

  • prostatic glandular cells: 1,078 nCPM
  • enterocytes: 790 nCPM
  • salivary acinar cells: 449 nCPM
  • epididymal clear cells: 421 nCPM
  • neutrophils: 408 nCPM
  • breast lactating cells: 358 nCPM

Immune cell

  • neutrophil: 841 nTPM
  • basophil: 748 nTPM
  • eosinophil: 522 nTPM
  • total PBMC: 451 nTPM
  • plasmacytoid DC: 390 nTPM
  • MAIT T-cell: 341 nTPM

Brain region

  • white matter: 71 nTPM
  • pons: 65 nTPM
  • medulla oblongata: 62 nTPM
  • cerebellum: 57 nTPM
  • spinal cord: 54 nTPM
  • hypothalamus: 49 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.49
gnomAD pLI
0
gnomAD missense Z
0.08
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DHRS7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DHRS7 as an antibody target. Whether an autoantibody or antibody against DHRS7 could matter depends on whether native DHRS7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DHRS7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DHRS7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DHRS7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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