Seroatlas · Human Serome Atlas

DHRS7B

Dehydrogenase/reductase SDR family member 7B

Also known as: CGI-93, DKFZp566O084, DRS7B_HUMAN, MGC8916, SDR32C1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6IAN0
Gene
DHRS7B
Ensembl
ENSG00000109016
Chromosome
17
Canonical length
325 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Plasma membrane,Cell Junctions,Cytosol

OverviewNCBI Gene

Predicted to enable acylglycerone-phosphate reductase (NADP+) activity. Predicted to be involved in ether lipid biosynthetic process. Predicted to act upstream of or within several processes, including brown fat cell differentiation; phosphatidylcholine biosynthetic process; and regulation of cold-induced thermogenesis. Located in membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

325 residues, UniProt reviewed canonical sequence.

>Q6IAN0|DHRS7B
     1  MVSPATRKSL PKVKAMDFIT STAILPLLFG CLGVFGLFRL LQWVRGKAYL RNAVVVITGA
    61  TSGLGKECAK VFYAAGAKLV LCGRNGGALE ELIRELTASH ATKVQTHKPY LVTFDLTDSG
   121  AIVAAAAEIL QCFGYVDILV NNAGISYRGT IMDTTVDVDK RVMETNYFGP VALTKALLPS
   181  MIKRRQGHIV AISSIQGKMS IPFRSAYAAS KHATQAFFDC LRAEMEQYEI EVTVISPGYI
   241  HTNLSVNAIT ADGSRYGVMD TTTAQGRSPV EVAQDVLAAV GKKKKDVILA DLLPSLAVYL
   301  RTLAPGLFFS LMASRARKER KSKNS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DHRS7B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
49 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 49 nTPM
  • parathyroid gland: 47 nTPM
  • choroid plexus: 44 nTPM
  • epididymis: 41 nTPM
  • tongue: 36 nTPM
  • kidney: 29 nTPM

Single-cell type

  • myonuclei: 207 nCPM
  • neutrophils: 189 nCPM
  • late primary spermatocytes: 151 nCPM
  • neutrophil progenitors: 131 nCPM
  • respiratory ciliated cells: 122 nCPM
  • cytotrophoblasts: 93 nCPM

Immune cell

  • non-classical monocyte: 61 nTPM
  • intermediate monocyte: 53 nTPM
  • classical monocyte: 53 nTPM
  • eosinophil: 41 nTPM
  • neutrophil: 36 nTPM
  • myeloid DC: 33 nTPM

Brain region

  • white matter: 24 nTPM
  • choroid plexus: 21 nTPM
  • medulla oblongata: 20 nTPM
  • spinal cord: 20 nTPM
  • cerebellum: 20 nTPM
  • hypothalamus: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.5
gnomAD pLI
0
gnomAD missense Z
0.75
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

  • acylglycerone-phosphate reductase (NADP+) activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DHRS7B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DHRS7B as an antibody target. Whether an autoantibody or antibody against DHRS7B could matter depends on whether native DHRS7B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DHRS7B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DHRS7B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DHRS7B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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