LDHAL6A
L-lactate dehydrogenase A-like 6A
Also known as: LDH6A, LDH6A_HUMAN, MGC23940
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6ZMR3
- Gene
- LDHAL6A
- Ensembl
- ENSG00000166800
- Chromosome
- 11
- Canonical length
- 332 aa
- Protein class
- Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
OverviewNCBI Gene
Enables L-lactate dehydrogenase activity. Predicted to be involved in lactate metabolic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
332 residues, UniProt reviewed canonical sequence.
>Q6ZMR3|LDHAL6A
1 MATIKSELIK NFAEEEAIHH NKISIVGTGS VGVACAISIL LKGLSDELVL VDVDEGKLKG
61 ETMDLQHGSP FMKMPNIVSS KDYLVTANSN LVIITAGARQ KKGETRLDLV QRNVSIFKLM
121 IPNITQYSPH CKLLIVTNPV DILTYVAWKL SGFPKNRVIG SGCNLDSARF RYFIGQRLGI
181 HSESCHGLIL GEHGDSSVPV WSGVNIAGVP LKDLNPDIGT DKDPEQWENV HKKVISSGYE
241 MVKMKGYTSW GISLSVADLT ESILKNLRRV HPVSTLSKGL YGINEDIFLS VPCILGENGI
301 TDLIKVKLTL EEEACLQKSA ETLWEIQKEL KLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against LDHAL6A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.26
- Highest tissue expression
- 8.6 nTPM
Expression across tissuesHPA
Tissue
- testis: 8.6 nTPM
- ovary: 1.3 nTPM
- retina: 1 nTPM
- bone marrow: 0.9 nTPM
- skin: 0.9 nTPM
- cerebellum: 0.5 nTPM
Single-cell type
- oocytes: 327 nCPM
- late primary spermatocytes: 59 nCPM
- epicardial cells: 25 nCPM
- cardiomyocytes: 11 nCPM
- adipocytes: 11 nCPM
- late spermatids: 11 nCPM
Immune cell
- basophil: 0.6 nTPM
- neutrophil: 0.6 nTPM
- gdT-cell: 0.3 nTPM
- memory B-cell: 0.2 nTPM
- naive B-cell: 0.2 nTPM
- naive CD4 T-cell: 0.2 nTPM
Brain region
- cerebellum: 6.4 nTPM
- cerebral cortex: 4 nTPM
- basal ganglia: 3.8 nTPM
- pons: 3.8 nTPM
- white matter: 3.7 nTPM
- hippocampal formation: 3.6 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.64
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.27
- DepMap mean gene effect
- 0.07
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Lactate/malate dehydrogenase, N-terminal
- L-lactate/malate dehydrogenase
- L-lactate dehydrogenase
- Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
- L-lactate dehydrogenase, active site
- Lactate/malate dehydrogenase, C-terminal
- NAD(P)-binding domain superfamily
- lactate/malate dehydrogenase, NAD binding domain
- lactate/malate dehydrogenase, alpha/beta C-terminal domain
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads LDHAL6A as an antibody target. Whether an autoantibody or antibody against LDHAL6A could matter depends on whether native LDHAL6A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
LDHAL6A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label LDHAL6A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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