Seroatlas · Human Serome Atlas

VAT1

Synaptic vesicle membrane protein VAT-1 homolog

Also known as: FLJ20230, VAT1_HUMAN, VATI

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99536
Gene: VAT1
Ensembl: ENSG00000108828
Chromosome: 17
Canonical length: 393 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Quaternary structure: Homotetramer

OverviewNCBI Gene

Synaptic vesicles are responsible for regulating the storage and release of neurotransmitters in the nerve terminal. The protein encoded by this gene is an abundant integral membrane protein of cholinergic synaptic vesicles and is thought to be involved in vesicular transport. It belongs to the quinone oxidoreductase subfamily of zinc-containing alcohol dehydrogenase proteins. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

393 residues, UniProt reviewed canonical sequence.

>Q99536|VAT1
     1  MSDEREVAEA ATGEDASSPP PKTEAASDPQ HPAASEGAAA AAASPPLLRC LVLTGFGGYD
    61  KVKLQSRPAA PPAPGPGQLT LRLRACGLNF ADLMARQGLY DRLPPLPVTP GMEGAGVVIA
   121  VGEGVSDRKA GDRVMVLNRS GMWQEEVTVP SVQTFLIPEA MTFEEAAALL VNYITAYMVL
   181  FDFGNLQPGH SVLVHMAAGG VGMAAVQLCR TVENVTVFGT ASASKHEALK ENGVTHPIDY
   241  HTTDYVDEIK KISPKGVDIV MDPLGGSDTA KGYNLLKPMG KVVTYGMANL LTGPKRNLMA
   301  LARTWWNQFS VTALQLLQAN RAVCGFHLGY LDGEVELVSG VVARLLALYN QGHIKPHIDS
   361  VWPFEKVADA MKQMQEKKNV GKVLLVPGPE KEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VAT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 241 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 241 nTPM
skin: 187 nTPM
adipose tissue: 175 nTPM
ovary: 160 nTPM
breast: 134 nTPM
cervix: 131 nTPM

Single-cell type

esophageal apical cells: 474 nCPM
hofbauer cells: 200 nCPM
melanocytes: 193 nCPM
mast cells: 81 nCPM
neutrophil progenitors: 78 nCPM
decidual stromal cells: 77 nCPM

Immune cell

basophil: 105 nTPM
eosinophil: 25 nTPM
memory B-cell: 20 nTPM
naive B-cell: 20 nTPM
total PBMC: 19 nTPM
memory CD4 T-cell: 19 nTPM

Brain region

pons: 328 nTPM
midbrain: 238 nTPM
hypothalamus: 232 nTPM
medulla oblongata: 145 nTPM
thalamus: 122 nTPM
white matter: 115 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0.01
gnomAD missense Z: 1.41
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VAT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VAT1 as an antibody target. Whether an autoantibody or antibody against VAT1 could matter depends on whether native VAT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VAT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VAT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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