Seroatlas · Human Serome Atlas

DHRSX

Polyprenol dehydrogenase

Also known as: DHRS5X, DHRS5Y, DHRSX_HUMAN, DHRSXY, DHRSY, SDR46C1, SDR7C6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N5I4
Gene
DHRSX
Ensembl
ENSG00000169084
Chromosome
X
Canonical length
330 aa
Protein class
Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Mitotic spindle,Cytosol
Secretome location
Secreted to blood

OverviewNCBI Gene

Enables dolichal reductase [NAD(P)+] activity and polyprenol dehydrogenase activity. Involved in dolichol biosynthetic process and positive regulation of autophagy. Located in extracellular region. Is active in lipid droplet. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

330 residues, UniProt reviewed canonical sequence.

>Q8N5I4|DHRSX
     1  MSPLSAARAA LRVYAVGAAV ILAQLLRRCR GGFLEPVFPP RPDRVAIVTG GTDGIGYSTA
    61  KHLARLGMHV IIAGNNDSKA KQVVSKIKEE TLNDKVEFLY CDLASMTSIR QFVQKFKMKK
   121  IPLHVLINNA GVMMVPQRKT RDGFEEHFGL NYLGHFLLTN LLLDTLKESG SPGHSARVVT
   181  VSSATHYVAE LNMDDLQSSA CYSPHAAYAQ SKLALVLFTY HLQRLLAAEG SHVTANVVDP
   241  GVVNTDVYKH VFWATRLAKK LLGWLLFKTP DEGAWTSIYA AVTPELEGVG GHYLYNEKET
   301  KSLHVTYNQK LQQQLWSKSC EMTGVLDVTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DHRSX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
29 nTPM

Expression across tissuesHPA

Tissue

  • liver: 29 nTPM
  • pancreas: 21 nTPM
  • heart muscle: 19 nTPM
  • choroid plexus: 17 nTPM
  • stomach: 16 nTPM
  • adrenal gland: 15 nTPM

Single-cell type

  • neutrophils: 984 nCPM
  • syncytiotrophoblasts: 328 nCPM
  • myonuclei: 267 nCPM
  • proximal tubule cells: 255 nCPM
  • cdc: 199 nCPM
  • pancreatic acinar cells: 196 nCPM

Immune cell

  • neutrophil: 57 nTPM
  • classical monocyte: 38 nTPM
  • myeloid DC: 35 nTPM
  • eosinophil: 35 nTPM
  • intermediate monocyte: 31 nTPM
  • plasmacytoid DC: 28 nTPM

Brain region

  • choroid plexus: 33 nTPM
  • medulla oblongata: 33 nTPM
  • thalamus: 31 nTPM
  • midbrain: 30 nTPM
  • spinal cord: 26 nTPM
  • pons: 26 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DHRSX.

Disease | AllUniProt

Conditions DHRSX is implicated in, by any mechanism.

  • Congenital disorder of glycosylation 1DD (CDG1DD) MIM:301133

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 232 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Congenital disorder of glycosylation, type 1DD

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.2
gnomAD pLI
0
gnomAD missense Z
0.24

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DHRSX as an antibody target. Whether an autoantibody or antibody against DHRSX could matter depends on whether native DHRSX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DHRSX is annotated as secreted, so native DHRSX circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label DHRSX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DHRSX. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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