RDH11

Protein identityUniProt · HPA

UniProt accession

Q8TC12

Gene

RDH11

Ensembl

ENSG00000072042

Chromosome

14

Canonical length

318 aa

Protein class

Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins

Secretome location

Intracellular and membrane

OverviewNCBI Gene

Enables all-trans-retinol dehydrogenase (NADP+) activity. Involved in cellular detoxification of aldehyde and retinoid metabolic process. Acts upstream of or within retinal metabolic process. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

318 residues, UniProt reviewed canonical sequence.

>Q8TC12|RDH11
     1  MVELMFPLLL LLLPFLLYMA APQIRKMLSS GVCTSTVQLP GKVVVVTGAN TGIGKETAKE
    61  LAQRGARVYL ACRDVEKGEL VAKEIQTTTG NQQVLVRKLD LSDTKSIRAF AKGFLAEEKH
   121  LHVLINNAGV MMCPYSKTAD GFEMHIGVNH LGHFLLTHLL LEKLKESAPS RIVNVSSLAH
   181  HLGRIHFHNL QGEKFYNAGL AYCHSKLANI LFTQELARRL KGSGVTTYSV HPGTVQSELV
   241  RHSSFMRWMW WLFSFFIKTP QQGAQTSLHC ALTEGLEILS GNHFSDCHVA WVSAQARNET
   301  IARRLWDVSC DLLGLPID

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RDH11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.25

Highest tissue expression

546 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RDH11.

Disease | AllUniProt

Conditions RDH11 is implicated in, by any mechanism.

• Retinal dystrophy, juvenile cataracts, and short stature syndrome (RDJCSS) MIM:616108

Disease | GeneticClinVar

9 pathogenic / likely-pathogenic of 230 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Retinitis pigmentosa-juvenile cataract-short stature-intellectual disability syndrome
• Retinal dystrophy

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.35

gnomAD pLI

0

gnomAD missense Z

0.55

DepMap mean gene effect

0.04

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular detoxification of aldehyde
• retinal metabolic process
• retinoid metabolic process
• retinol metabolic process
• visual perception

Molecular functions

• 11-cis-retinol dehydrogenase (NADP+) activity
• all-trans-retinol dehydrogenase (NAD+) activity
• all-trans-retinol dehydrogenase (NADP+) activity
• oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
• aldehyde dehydrogenase (NADP+) activity

Cellular components

• endoplasmic reticulum membrane
• photoreceptor inner segment

Protein domainsUniProt · Pfam · InterPro

• Short-chain dehydrogenase/reductase SDR
• NAD(P)-binding domain superfamily
• short chain dehydrogenase

KeywordsUniProt

• Acetylation
• Cataract
• Dwarfism
• Endoplasmic reticulum
• Lipid metabolism
• Membrane
• NADP
• Oxidoreductase
• Signal-anchor
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of RDH11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SELENOF
• ESYT1