Seroatlas · Human Serome Atlas

SDR39U1

Epimerase family protein SDR39U1

Also known as: C14orf124, D39U1_HUMAN, HCDI

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NRG7
Gene: SDR39U1
Ensembl: ENSG00000100445
Chromosome: 14
Canonical length: 293 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) superfamily, which includes both classical and extended types. The encoded protein represents an extended type, with similarity to epimerases. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Mar 2014]

Canonical amino-acid sequenceUniProt

293 residues, UniProt reviewed canonical sequence.

>Q9NRG7|SDR39U1
     1  MRVLVGGGTG FIGTALTQLL NARGHEVTLV SRKPGPGRIT WDELAASGLP SCDAAVNLAG
    61  ENILNPLRRW NETFQKEVIG SRLETTQLLA KAITKAPQPP KAWVLVTGVA YYQPSLTAEY
   121  DEDSPGGDFD FFSNLVTKWE AAARLPGDST RQVVVRSGVV LGRGGGAMGH MLLPFRLGLG
   181  GPIGSGHQFF PWIHIGDLAG ILTHALEANH VHGVLNGVAP SSATNAEFAQ TLGAALGRRA
   241  FIPLPSAVVQ AVFGRQRAIM LLEGQKVIPQ RTLATGYQYS FPELGAALKE IVA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SDR39U1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 96 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 96 nTPM
heart muscle: 83 nTPM
adrenal gland: 76 nTPM
tongue: 70 nTPM
kidney: 66 nTPM
midbrain: 66 nTPM

Single-cell type

epicardial cells: 71 nCPM
syncytiotrophoblasts: 70 nCPM
breast lactating cells: 62 nCPM
early primary spermatocytes: 59 nCPM
epididymal principal cells: 56 nCPM
cytotrophoblasts: 56 nCPM

Immune cell

plasmacytoid DC: 62 nTPM
NK-cell: 60 nTPM
naive B-cell: 51 nTPM
memory B-cell: 51 nTPM
naive CD8 T-cell: 46 nTPM
myeloid DC: 44 nTPM

Brain region

cerebellum: 49 nTPM
thalamus: 47 nTPM
midbrain: 46 nTPM
spinal cord: 44 nTPM
white matter: 43 nTPM
medulla oblongata: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.62
gnomAD pLI: 0
gnomAD missense Z: -0.29
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

oxidoreductase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

NAD-dependent epimerase/dehydratase
NAD(P)-binding domain superfamily
NAD dependent epimerase/dehydratase family
Epimerase family protein SDR39U1
Domain of unknown function DUF1731
Domain of unknown function (DUF1731)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SDR39U1 as an antibody target. Whether an autoantibody or antibody against SDR39U1 could matter depends on whether native SDR39U1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SDR39U1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SDR39U1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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