Seroatlas · Human Serome Atlas

RDH10

Retinol dehydrogenase 10

Also known as: RDH10_HUMAN, SDR16C4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IZV5
Gene: RDH10
Ensembl: ENSG00000121039
Chromosome: 8
Canonical length: 341 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Lipid droplets

OverviewNCBI Gene

This gene encodes a retinol dehydrogenase, which converts all-trans-retinol to all-trans-retinal, with preference for NADP as a cofactor. Studies in mice suggest that this protein is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

341 residues, UniProt reviewed canonical sequence.

>Q8IZV5|RDH10
     1  MNIVVEFFVV TFKVLWAFVL AAARWLVRPK EKSVAGQVCL ITGAGSGLGR LFALEFARRR
    61  ALLVLWDINT QSNEETAGMV RHIYRDLEAA DAAALQAGNG EEEILPHCNL QVFTYTCDVG
   121  KRENVYLTAE RVRKEVGEVS VLVNNAGVVS GHHLLECPDE LIERTMMVNC HAHFWTTKAF
   181  LPTMLEINHG HIVTVASSLG LFSTAGVEDY CASKFGVVGF HESLSHELKA AEKDGIKTTL
   241  VCPYLVDTGM FRGCRIRKEI EPFLPPLKPD YCVKQAMKAI LTDQPMICTP RLMYIVTFMK
   301  SILPFEAVVC MYRFLGADKC MYPFIAQRKQ ATNNNEAKNG I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RDH10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 80 nTPM

Expression across tissuesHPA

Tissue

retina: 80 nTPM
urinary bladder: 64 nTPM
kidney: 41 nTPM
adipose tissue: 41 nTPM
liver: 38 nTPM
salivary gland: 37 nTPM

Single-cell type

retinal pigment epithelial cells: 921 nCPM
salivary duct cells: 569 nCPM
conjunctival goblet cells: 565 nCPM
müller glia: 335 nCPM
respiratory secretory cells: 286 nCPM
respiratory deuterosomal cells: 245 nCPM

Immune cell

naive CD4 T-cell: 0.6 nTPM
memory CD8 T-cell: 0.4 nTPM
gdT-cell: 0.3 nTPM
memory CD4 T-cell: 0.3 nTPM
naive CD8 T-cell: 0.3 nTPM
basophil: 0.2 nTPM

Brain region

thalamus: 42 nTPM
choroid plexus: 31 nTPM
medulla oblongata: 22 nTPM
pons: 12 nTPM
white matter: 12 nTPM
hypothalamus: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.23
gnomAD pLI: 0.99
gnomAD missense Z: 3.03
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

bud elongation involved in lung branching
ear development
embryonic camera-type eye development
embryonic forelimb morphogenesis
embryonic viscerocranium morphogenesis
gonad development
in utero embryonic development
metanephros development
neural crest cell development
nose development
retinal metabolic process
retinoic acid biosynthetic process
retinoid metabolic process
retinol metabolic process
visual perception
positive regulation of retinoic acid biosynthetic process
primary lung bud formation

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RDH10 as an antibody target. Whether an autoantibody or antibody against RDH10 could matter depends on whether native RDH10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RDH10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RDH10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...