Seroatlas · Human Serome Atlas

RDH16

Retinol dehydrogenase 16

Also known as: RDH16_HUMAN, RODH-4, SDR9C8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75452
Gene: RDH16
Ensembl: ENSG00000139547
Chromosome: 12
Canonical length: 317 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables all-trans-retinol dehydrogenase (NAD+) activity; androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity; and androsterone dehydrogenase [NAD(P)+] activity. Involved in steroid metabolic process. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

317 residues, UniProt reviewed canonical sequence.

>O75452|RDH16
     1  MWLYLAVFVG LYYLLHWYRE RQVLSHLRDK YVFITGCDSG FGKLLARQLD ARGLRVLAAC
    61  LTEKGAEQLR GQTSDRLETV TLDVTKTESV AAAAQWVKEC VRDKGLWGLV NNAGISLPTA
   121  PNELLTKQDF VTILDVNLLG VIDVTLSLLP LVRRARGRVV NVSSVMGRVS LFGGGYCISK
   181  YGVEAFSDSL RRELSYFGVK VAMIEPGYFK TAVTSKERFL KSFLEIWDRS SPEVKEAYGE
   241  KFVADYKKSA EQMEQKCTQD LSLVTNCMEH ALIACHPRTR YSAGWDAKLL YLPMSYMPTF
   301  LVDAIMYWVS PSPAKAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RDH16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 813 nTPM

Expression across tissuesHPA

Tissue

liver: 813 nTPM
prostate: 6.8 nTPM
skin: 4.1 nTPM
spleen: 3.1 nTPM
cervix: 2.7 nTPM
seminal vesicle: 2.2 nTPM

Single-cell type

hepatocytes: 416 nCPM
prostatic glandular cells: 24 nCPM
early spermatids: 15 nCPM
late spermatids: 12 nCPM
hepatic stellate cells: 6.5 nCPM
esophageal suprabasal cells: 5.5 nCPM

Immune cell

gdT-cell: 0.3 nTPM
memory CD8 T-cell: 0.1 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

white matter: 0.4 nTPM
amygdala: 0.3 nTPM
basal ganglia: 0.3 nTPM
cerebellum: 0.3 nTPM
cerebral cortex: 0.3 nTPM
choroid plexus: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.59
gnomAD pLI: 0
gnomAD missense Z: -0.1
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RDH16 as an antibody target. Whether an autoantibody or antibody against RDH16 could matter depends on whether native RDH16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RDH16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RDH16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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