Seroatlas · Human Serome Atlas

HSDL1

Inactive hydroxysteroid dehydrogenase-like protein 1

Also known as: HSDL1_HUMAN, SDR12C3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q3SXM5
Gene
HSDL1
Ensembl
ENSG00000103160
Chromosome
16
Canonical length
330 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Vesicles,Intermediate filaments,Mitochondria

OverviewNCBI Gene

Located in intermediate filament cytoskeleton and mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

330 residues, UniProt reviewed canonical sequence.

>Q3SXM5|HSDL1
     1  MAAVDSFYLL YREIARSCNC YMEALALVGA WYTARKSITV ICDFYSLIRL HFIPRLGSRA
    61  DLIKQYGRWA VVSGATDGIG KAYAEELASR GLNIILISRN EEKLQVVAKD IADTYKVETD
   121  IIVADFSSGR EIYLPIREAL KDKDVGILVN NVGVFYPYPQ YFTQLSEDKL WDIINVNIAA
   181  ASLMVHVVLP GMVERKKGAI VTISSGSCCK PTPQLAAFSA SKAYLDHFSR ALQYEYASKG
   241  IFVQSLIPFY VATSMTAPSN FLHRCSWLVP SPKVYAHHAV STLGISKRTT GYWSHSIQFL
   301  FAQYMPEWLW VWGANILNRS LRKEALSCTA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSDL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
32 nTPM

Expression across tissuesHPA

Tissue

  • retina: 32 nTPM
  • tongue: 29 nTPM
  • thyroid gland: 25 nTPM
  • skeletal muscle: 19 nTPM
  • cerebral cortex: 19 nTPM
  • ovary: 18 nTPM

Single-cell type

  • platelets: 61 nCPM
  • late primary spermatocytes: 59 nCPM
  • rod photoreceptor cells: 46 nCPM
  • somatotrophs: 41 nCPM
  • differentiating spermatogonia: 37 nCPM
  • respiratory ciliated cells: 36 nCPM

Immune cell

  • basophil: 21 nTPM
  • eosinophil: 11 nTPM
  • naive B-cell: 7.6 nTPM
  • non-classical monocyte: 6.4 nTPM
  • naive CD8 T-cell: 5.6 nTPM
  • neutrophil: 5.5 nTPM

Brain region

  • pons: 41 nTPM
  • hypothalamus: 40 nTPM
  • midbrain: 33 nTPM
  • basal ganglia: 31 nTPM
  • medulla oblongata: 31 nTPM
  • cerebral cortex: 30 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HSDL1.

Disease | ImmuneIEDB

Conditions an epitope on HSDL1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.92
gnomAD pLI
0
gnomAD missense Z
-1.08
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HSDL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSDL1 as an antibody target. Whether an autoantibody or antibody against HSDL1 could matter depends on whether native HSDL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSDL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HSDL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HSDL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...