Seroatlas · Human Serome Atlas

ADH6

Alcohol dehydrogenase 6

Also known as: ADH-5, ADH6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P28332
Gene: ADH6
Ensembl: ENSG00000172955
Chromosome: 4
Canonical length: 368 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes class V alcohol dehydrogenase, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This gene is expressed in the stomach as well as in the liver, and it contains a glucocorticoid response element upstream of its 5' UTR, which is a steroid hormone receptor binding site. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

368 residues, UniProt reviewed canonical sequence.

>P28332|ADH6
     1  MSTTGQVIRC KAAILWKPGA PFSIEEVEVA PPKAKEVRIK VVATGLCGTE MKVLGSKHLD
    61  LLYPTILGHE GAGIVESIGE GVSTVKPGDK VITLFLPQCG ECTSCLNSEG NFCIQFKQSK
   121  TQLMSDGTSR FTCKGKSIYH FGNTSTFCEY TVIKEISVAK IDAVAPLEKV CLISCGFSTG
   181  FGAAINTAKV TPGSTCAVFG LGGVGLSVVM GCKAAGAARI IGVDVNKEKF KKAQELGATE
   241  CLNPQDLKKP IQEVLFDMTD AGIDFCFEAI GNLDVLAAAL ASCNESYGVC VVVGVLPASV
   301  QLKISGQLFF SGRSLKGSVF GGWKSRQHIP KLVADYMAEK LNLDPLITHT LNLDKINEAV
   361  ELMKTGKW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADH6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 658 nTPM

Expression across tissuesHPA

Tissue

liver: 658 nTPM
kidney: 49 nTPM
duodenum: 39 nTPM
small intestine: 21 nTPM
fallopian tube: 8.7 nTPM
rectum: 8.1 nTPM

Single-cell type

hepatocytes: 437 nCPM
epicardial cells: 39 nCPM
neuroendocrine cells: 39 nCPM
tuft cells: 35 nCPM
fallopian tube ciliated cells: 33 nCPM
enterocytes: 32 nCPM

Immune cell

neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

white matter: 0.9 nTPM
midbrain: 0.7 nTPM
medulla oblongata: 0.6 nTPM
spinal cord: 0.5 nTPM
amygdala: 0.4 nTPM
basal ganglia: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0
gnomAD missense Z: 0.6
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADH6 as an antibody target. Whether an autoantibody or antibody against ADH6 could matter depends on whether native ADH6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADH6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ADH6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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