Seroatlas · Human Serome Atlas

DHRS11

Dehydrogenase/reductase SDR family member 11

Also known as: DHR11_HUMAN, MGC4172, SDR24C1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UWP2
Gene: DHRS11
Ensembl: ENSG00000278535
Chromosome: 17
Canonical length: 260 aa
Protein class: Enzymes, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Golgi apparatus,Cytosol
Secretome location: Secreted to digestive system
Quaternary structure: Homotetramer

OverviewNCBI Gene

Enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity; 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity; and estradiol 17-beta-dehydrogenase [NAD(P)+] activity. Involved in steroid biosynthetic process. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

260 residues, UniProt reviewed canonical sequence.

>Q6UWP2|DHRS11
     1  MARPGMERWR DRLALVTGAS GGIGAAVARA LVQQGLKVVG CARTVGNIEE LAAECKSAGY
    61  PGTLIPYRCD LSNEEDILSM FSAIRSQHSG VDICINNAGL ARPDTLLSGS TSGWKDMFNV
   121  NVLALSICTR EAYQSMKERN VDDGHIININ SMSGHRVLPL SVTHFYSATK YAVTALTEGL
   181  RQELREAQTH IRATCISPGV VETQFAFKLH DKDPEKAAAT YEQMKCLKPE DVAEAVIYVL
   241  STPAHIQIGD IQMRPTEQVT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DHRS11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 203 nTPM

Expression across tissuesHPA

Tissue

duodenum: 203 nTPM
small intestine: 167 nTPM
colon: 70 nTPM
rectum: 54 nTPM
cerebral cortex: 28 nTPM
retina: 21 nTPM

Single-cell type

other brain neurons: 14 nCPM
brain inhibitory neurons: 13 nCPM
choroid plexus epithelial cells: 12 nCPM
enterocytes: 11 nCPM
brain excitatory neurons: 11 nCPM
distal convoluted tubule cells: 8.6 nCPM

Immune cell

T-reg: 0.7 nTPM
eosinophil: 0.3 nTPM
intermediate monocyte: 0.3 nTPM
naive CD4 T-cell: 0.3 nTPM
memory CD4 T-cell: 0.2 nTPM
basophil: 0.1 nTPM

Brain region

cerebral cortex: 14 nTPM
choroid plexus: 12 nTPM
hypothalamus: 12 nTPM
thalamus: 11 nTPM
pons: 9.5 nTPM
white matter: 9.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.33
gnomAD pLI: 0
gnomAD missense Z: 0.53
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DHRS11 as an antibody target. Whether an autoantibody or antibody against DHRS11 could matter depends on whether native DHRS11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DHRS11 is annotated as secreted, so native DHRS11 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label DHRS11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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