PTGR2
Prostaglandin reductase 2
Also known as: FLJ39091, PTGR2_HUMAN, ZADH1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N8N7
- Gene
- PTGR2
- Ensembl
- ENSG00000140043
- Chromosome
- 14
- Canonical length
- 351 aa
- Protein class
- Enzymes, Predicted intracellular proteins
- Subcellular location
- Vesicles
OverviewNCBI Gene
This gene encodes an enzyme involved in the metabolism of prostaglandins. The encoded protein catalyzes the NADPH-dependent conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2. This protein may also be involved in regulating activation of the peroxisome proliferator-activated receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Canonical amino-acid sequenceUniProt
351 residues, UniProt reviewed canonical sequence.
>Q8N8N7|PTGR2
1 MIVQRVVLNS RPGKNGNPVA ENFRMEEVYL PDNINEGQVQ VRTLYLSVDP YMRCRMNEDT
61 GTDYITPWQL SQVVDGGGIG IIEESKHTNL TKGDFVTSFY WPWQTKVILD GNSLEKVDPQ
121 LVDGHLSYFL GAIGMPGLTS LIGIQEKGHI TAGSNKTMVV SGAAGACGSV AGQIGHFLGC
181 SRVVGICGTH EKCILLTSEL GFDAAINYKK DNVAEQLRES CPAGVDVYFD NVGGNISDTV
241 ISQMNENSHI ILCGQISQYN KDVPYPPPLS PAIEAIQKER NITRERFLVL NYKDKFEPGI
301 LQLSQWFKEG KLKIKETVIN GLENMGAAFQ SMMTGGNIGK QIVCISEEIS LLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PTGR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.23
- Highest tissue expression
- 31 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 31 nTPM
- tongue: 30 nTPM
- heart muscle: 26 nTPM
- liver: 18 nTPM
- kidney: 18 nTPM
- epididymis: 16 nTPM
Single-cell type
- choroid plexus epithelial cells: 37 nCPM
- ependymal cells: 33 nCPM
- bergmann glia: 22 nCPM
- oligodendrocytes: 22 nCPM
- astrocytes: 18 nCPM
- brain inhibitory neurons: 14 nCPM
Immune cell
- basophil: 6.2 nTPM
- naive CD4 T-cell: 1.7 nTPM
- naive CD8 T-cell: 1.4 nTPM
- myeloid DC: 1.2 nTPM
- NK-cell: 1.2 nTPM
- plasmacytoid DC: 1.2 nTPM
Brain region
- white matter: 15 nTPM
- medulla oblongata: 14 nTPM
- midbrain: 14 nTPM
- hypothalamus: 14 nTPM
- choroid plexus: 13 nTPM
- spinal cord: 12 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.08
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.8
- DepMap mean gene effect
- 0.09
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PTGR2 as an antibody target. Whether an autoantibody or antibody against PTGR2 could matter depends on whether native PTGR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PTGR2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PTGR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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