TP53I3

Protein identityUniProt · HPA

UniProt accession

Q53FA7

Gene

TP53I3

Ensembl

ENSG00000115129

Chromosome

2

Canonical length

332 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Vesicles

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Canonical amino-acid sequenceUniProt

332 residues, UniProt reviewed canonical sequence.

>Q53FA7|TP53I3
     1  MLAVHFDKPG GPENLYVKEV AKPSPGEGEV LLKVAASALN RADLMQRQGQ YDPPPGASNI
    61  LGLEASGHVA ELGPGCQGHW KIGDTAMALL PGGGQAQYVT VPEGLLMPIP EGLTLTQAAA
   121  IPEAWLTAFQ LLHLVGNVQA GDYVLIHAGL SGVGTAAIQL TRMAGAIPLV TAGSQKKLQM
   181  AEKLGAAAGF NYKKEDFSEA TLKFTKGAGV NLILDCIGGS YWEKNVNCLA LDGRWVLYGL
   241  MGGGDINGPL FSKLLFKRGS LITSLLRSRD NKYKQMLVNA FTEQILPHFS TEGPQRLLPV
   301  LDRIYPVTEI QEAHKYMEAN KNIGKIVLEL PQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TP53I3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.23

Highest tissue expression

122 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.66

gnomAD pLI

0

gnomAD missense Z

0.51

DepMap mean gene effect

-0.19

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• reactive oxygen species biosynthetic process

Molecular functions

• NADPH binding
• quinone binding
• quinone reductase (NADPH) activity

Cellular components

• cytosol

Protein domainsUniProt · Pfam · InterPro

• GroES-like superfamily
• Alcohol dehydrogenase-like, C-terminal
• Alcohol dehydrogenase-like, N-terminal
• Enoylreductase domain
• NAD(P)-binding domain superfamily
• Zinc-binding dehydrogenase
• Alcohol dehydrogenase GroES-like domain
• Quinone oxidoreductase PIG3

KeywordsUniProt

• Acetylation
• NADP
• Oxidoreductase