Seroatlas · Human Serome Atlas

DHRS7C

Dehydrogenase/reductase SDR family member 7C

Also known as: DRS7C_HUMAN, SDR32C2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NNS2
Gene
DHRS7C
Ensembl
ENSG00000184544
Chromosome
17
Canonical length
312 aa
Protein class
Enzymes, Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted in other tissues

OverviewNCBI Gene

Predicted to enable all-trans-retinol dehydrogenase (NAD+) activity. Predicted to be involved in D-glucose import; intracellular calcium ion homeostasis; and regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. Predicted to be located in longitudinal sarcoplasmic reticulum and sarcoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>A6NNS2|DHRS7C
     1  MGVMAMLMLP LLLLGISGLL FIYQEVSRLW SKSAVQNKVV VITDAISGLG KECARVFHTG
    61  GARLVLCGKN WERLENLYDA LISVADPSKQ TFTPKLVLLD LSDISCVPDV AKEVLDCYGC
   121  VDILINNASV KVKGPAHKIS LELDKKIMDA NYFGPITLTK ALLPNMISRR TGQIVLVNNI
   181  QGKFGIPFRT TYAASKHAAL GFFDCLRAEV EEYDVVISTV SPTFIRSYHV YPEQGNWEAS
   241  IWKFFFRKLT YGVHPVEVAE EVMRTVRRKK QEVFMANPIP KAAVYVRTFF PEFFFAVVAC
   301  GVKEKLNVPE EG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DHRS7C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
343 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 343 nTPM
  • skeletal muscle: 289 nTPM
  • heart muscle: 102 nTPM
  • esophagus: 3.7 nTPM
  • salivary gland: 2.3 nTPM
  • rectum: 1 nTPM

Single-cell type

  • late spermatids: 28 nCPM
  • myonuclei: 22 nCPM
  • early spermatids: 7.9 nCPM
  • corticotrophs: 5 nCPM
  • cardiomyocytes: 4.2 nCPM
  • thymic myoid cells: 4.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.9 nTPM
  • white matter: 0.9 nTPM
  • basal ganglia: 0.4 nTPM
  • hippocampal formation: 0.3 nTPM
  • amygdala: 0.2 nTPM
  • spinal cord: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.5
gnomAD pLI
0
gnomAD missense Z
0.35
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DHRS7C as an antibody target. Whether an autoantibody or antibody against DHRS7C could matter depends on whether native DHRS7C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DHRS7C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DHRS7C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DHRS7C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...