Seroatlas · Human Serome Atlas

HSD11B1L

Hydroxysteroid 11-beta-dehydrogenase 1-like protein

Also known as: DHI1L_HUMAN, HSD1L, SCDR10, SDR26C2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z5J1
Gene: HSD11B1L
Ensembl: ENSG00000167733
Chromosome: 19
Canonical length: 315 aa
Protein class: Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Subcellular location: Vesicles
Secretome location: Secreted in brain

OverviewNCBI Gene

This gene is a member of the hydroxysteroid dehydrogenase family. The encoded protein is similar to an enzyme that catalyzes the interconversion of inactive to active glucocorticoids (e.g. cortisone). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]

Canonical amino-acid sequenceUniProt

315 residues, UniProt reviewed canonical sequence.

>Q7Z5J1|HSD11B1L
     1  MKVLLLTGLG ALFFAYYWDD NFDPASLQGA RVLLTGANAG VGEELAYHYA RLGSHLVLTA
    61  HTEALLQKVV GNCRKLGAPK VFYIAADMAS PEAPESVVQF ALDKLGGLDY LVLNHIGGAP
   121  AGTRARSPQA TRWLMQVNFV SYVQLTSRAL PSLTDSKGSL VVVSSLLGRV PTSFSTPYSA
   181  AKFALDGFFG SLRRELDVQD VNVAITMCVL GLRDRASAAE AVRSSTSRPR QPEHRGVPLQ
   241  SQTAMFLPPT VPGARTLTET PLRGWPQPKM KSSRQKSKTE KNDGHLEPVT AWEVQVPRVR
   301  RLCRGLARPH LFGHD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSD11B1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 89 nTPM

Expression across tissuesHPA

Tissue

amygdala: 89 nTPM
cerebral cortex: 82 nTPM
hippocampal formation: 69 nTPM
basal ganglia: 44 nTPM
hypothalamus: 40 nTPM
midbrain: 27 nTPM

Single-cell type

epididymal efferent duct ciliated cells: 25 nCPM
fallopian tube ciliated cells: 21 nCPM
epididymal clear cells: 14 nCPM
respiratory ciliated cells: 12 nCPM
epididymal principal cells: 11 nCPM
endometrial ciliated cells: 11 nCPM

Immune cell

intermediate monocyte: 2.7 nTPM
plasmacytoid DC: 2.2 nTPM
naive CD4 T-cell: 1.8 nTPM
non-classical monocyte: 1.8 nTPM
naive CD8 T-cell: 1.7 nTPM
neutrophil: 1.7 nTPM

Brain region

cerebral cortex: 58 nTPM
amygdala: 50 nTPM
hippocampal formation: 47 nTPM
basal ganglia: 47 nTPM
hypothalamus: 41 nTPM
white matter: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0
gnomAD missense Z: 1.46
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSD11B1L as an antibody target. Whether an autoantibody or antibody against HSD11B1L could matter depends on whether native HSD11B1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSD11B1L is annotated as secreted, so native HSD11B1L circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label HSD11B1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...