Seroatlas · Human Serome Atlas

UGDH

UDP-glucose 6-dehydrogenase

Also known as: UGDH_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O60701
Gene
UGDH
Ensembl
ENSG00000109814
Chromosome
4
Canonical length
494 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm
Quaternary structure
Homohexamer

OverviewNCBI Gene

The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

494 residues, UniProt reviewed canonical sequence.

>O60701|UGDH
     1  MFEIKKICCI GAGYVGGPTC SVIAHMCPEI RVTVVDVNES RINAWNSPTL PIYEPGLKEV
    61  VESCRGKNLF FSTNIDDAIK EADLVFISVN TPTKTYGMGK GRAADLKYIE ACARRIVQNS
   121  NGYKIVTEKS TVPVRAAESI RRIFDANTKP NLNLQVLSNP EFLAEGTAIK DLKNPDRVLI
   181  GGDETPEGQR AVQALCAVYE HWVPREKILT TNTWSSELSK LAANAFLAQR ISSINSISAL
   241  CEATGADVEE VATAIGMDQR IGNKFLKASV GFGGSCFQKD VLNLVYLCEA LNLPEVARYW
   301  QQVIDMNDYQ RRRFASRIID SLFNTVTDKK IAILGFAFKK DTGDTRESSS IYISKYLMDE
   361  GAHLHIYDPK VPREQIVVDL SHPGVSEDDQ VSRLVTISKD PYEACDGAHA VVICTEWDMF
   421  KELDYERIHK KMLKPAFIFD GRRVLDGLHN ELQTIGFQIE TIGKKVSSKR IPYAPSGEIP
   481  KFSLQDPPNK KPKV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UGDH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
129 nTPM

Expression across tissuesHPA

Tissue

  • liver: 129 nTPM
  • colon: 90 nTPM
  • rectum: 69 nTPM
  • urinary bladder: 51 nTPM
  • adipose tissue: 45 nTPM
  • stomach: 45 nTPM

Single-cell type

  • colonocytes: 642 nCPM
  • breast hormone-responsive cells: 439 nCPM
  • pancreatic acinar cells: 404 nCPM
  • enterocytes: 402 nCPM
  • hepatocytes: 346 nCPM
  • goblet cells: 301 nCPM

Immune cell

  • NK-cell: 42 nTPM
  • MAIT T-cell: 38 nTPM
  • basophil: 30 nTPM
  • memory CD8 T-cell: 25 nTPM
  • gdT-cell: 23 nTPM
  • plasmacytoid DC: 23 nTPM

Brain region

  • choroid plexus: 44 nTPM
  • cerebellum: 26 nTPM
  • cerebral cortex: 25 nTPM
  • white matter: 25 nTPM
  • thalamus: 25 nTPM
  • hypothalamus: 24 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about UGDH.

Disease | AllUniProt

Conditions UGDH is implicated in, by any mechanism.

  • Developmental and epileptic encephalopathy 84 (DEE84) MIM:618792

Disease | GeneticClinVar

26 pathogenic / likely-pathogenic of 126 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.72
gnomAD pLI
0
gnomAD missense Z
2.3
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
  • NAD(P)-binding domain superfamily
  • UDP-glucose/GDP-mannose dehydrogenase, N-terminal
  • UDP-glucose/GDP-mannose dehydrogenase, dimerisation
  • UDP-glucose/GDP-mannose dehydrogenase, C-terminal
  • UDP-glucose/GDP-mannose dehydrogenase
  • UDP-glucose 6-dehydrogenase, eukaryotic type
  • UDP-glucose/GDP-mannose dehydrogenase, C-terminal domain superfamily
  • UDP-glucose/GDP-mannose dehydrogenase family, central domain
  • UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
  • UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UGDH as an antibody target. Whether an autoantibody or antibody against UGDH could matter depends on whether native UGDH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UGDH is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UGDH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UGDH. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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